The clinical presentation and outcome of urothelial atypia on biopsy of the bladder

Justin B. Ziemba, Ron Golan, Alexander Skokan, Darshan Patel, Michael D. Feldman, Zhanyong Bing, Thomas J. Guzzo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objectives: To examine the presentation and clinical outcome of patients diagnosed with reactive urothelial atypia (RUA) or urothelial atypia of unknown significance (AUS) on tissue biopsy of the bladder. Methods and materials: We performed a retrospective cohort study of all patients who were diagnosed with either RUA or AUS on biopsy of the bladder at our institution from November 2000 to May 2008. Excluded from the analysis were patients with a history of or a concurrent diagnosis of urothelial carcinoma. A total of 66 patients were available for final analysis. Results: The mean patient age at diagnosis was 63 years (range: 18-89 years). There were 46 men (70%) and 20 women (30%). The indication for cystoscopic examination included lower urinary tract symptoms in 29 (44%), gross hematuria in 17 (26%), microscopic hematuria in 12 (18%), urolithiasis in 2 (3%), and hydronephrosis in 6 (9%) patients. On biopsy, 54 (82%) had RUA and 12 (18%) had AUS. The mean follow-up was 36 months (range: 0-271 months). During this period, 37 (56%) patients underwent at least 1 additional cystoscopy with negative result. None of the 66 (0%) patients developed biopsy-proven urothelial carcinoma. Conclusion: Urothelial atypia is common in men older than 60 years and often presents with either hematuria or lower urinary tract symptoms. Both RUA and AUS have a similar benign clinical course. Therefore, after diagnosis, further intervention or surveillance is unnecessary.

Original languageEnglish (US)
Pages (from-to)645-647
Number of pages3
JournalUrologic Oncology: Seminars and Original Investigations
Issue number5
StatePublished - Jul 2014
Externally publishedYes


  • Biopsy
  • Disease progression
  • Intraepithelial neoplasms
  • Neoplasms
  • Urinary bladder
  • Urothelium

ASJC Scopus subject areas

  • Oncology
  • Urology


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