The clearance of manganese chloride in the primate

M. Christopher Newland, Christopher Cox, Rikuzo Hamada, Günter Oberdörster, Bernard Weiss

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

The Clearance of Manganese Chloride in the Primate. NEWLAND, M. C., COX, C., HAMADA, R., OBERDÖRSTER, G., AND WEISS, B. (1987). Fundam. Appl Toxicol 9, 314-328. Two macaque monkeys inhaled trace amounts of 54MnCl2 for 30 min. Subsequently the chest, head, and fecal radioactivity were monitored for over a year. The chest data curve required a sum of three exponential terms, with half-times ranging from 0.2 to 187 days, to attain a satisfactory fit. Head levels peaked 40 days after acute inhalation exposure and remained elevated for over a year. The excretion of manganese through the feces was best described by a sum of two exponentials. One had a half-time of less than 1 day and the second had a half-time of 50 to 60 days. A third macaque received a 6-week continuous exposure to 54Mn through a subcutaneous osmotic pump. With this route, manganese clearance from the head occurred at a faster rate than after acute inhalation exposure. Fecal elimination following continuous subcutaneous exposure resembled that following acute inhalation. Kinetic analyses suggested that the long half-times of manganese in the head following inhalation reflected both slow disappearance from the head and replenishment from other depots.

Original languageEnglish (US)
Pages (from-to)314-328
Number of pages15
JournalToxicological Sciences
Volume9
Issue number2
DOIs
StatePublished - Aug 1987
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology

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