The Chronnectome: Time-Varying Connectivity Networks as the Next Frontier in fMRI Data Discovery

Vince D. Calhoun, Robyn Miller, Godfrey Pearlson, Tulay Adali

Research output: Contribution to journalReview articlepeer-review

614 Scopus citations


Recent years have witnessed a rapid growth of interest in moving functional magnetic resonance imaging (fMRI) beyond simple scan-length averages and into approaches that capture time-varying properties of connectivity. In this Perspective we use the term "chronnectome" to describe metrics that allow a dynamic view of coupling. In the chronnectome, coupling refers to possibly time-varying levels of correlated or mutually informed activity between brain regions whose spatial properties may also be temporally evolving. We primarily focus on multivariate approaches developed in our group and review a number of approaches with an emphasis on matrix decompositions such as principle component analysis and independent component analysis. We also discuss the potential these approaches offer to improve characterization and understanding of brain function. There are a number of methodological directions that need to be developed further, but chronnectome approaches already show great promise for the study of both the healthy and the diseased brain. Recent efforts in functional brain imaging are examining dynamics in brain connectivity. Here, we discuss evidence for time-varying connectivity (which we call the "chronnectome"), review approaches for capturing dynamic coupling, and show how dynamic connectivity can be used to study the healthy and the diseased brain.

Original languageEnglish (US)
Pages (from-to)262-274
Number of pages13
Issue number2
StatePublished - Oct 22 2014

ASJC Scopus subject areas

  • General Neuroscience


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