The changing field of vaccine development in the genomics era

Vladimir Brusic, J. Thomas August

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


An improved understanding of the human immune system and the genetic make-up of pathogens, together with advances in instrumentation and bioinformatics, have provided new insights into the variation of immune responses to vaccines within the human population. Pathogen variation and the diversity of the immune system components within the human population make the design of universal vaccines difficult. New subunit vaccines that target immunologically similar subgroups of the human population and representative pathogen variants are emerging from research that combines immunomics, pathogen genomics, and high-throughput instrumentation. 2004

Original languageEnglish (US)
Pages (from-to)597-600
Number of pages4
Issue number6
StatePublished - Sep 1 2004


  • Immune system diversity
  • Immunomics
  • Pathogen diversity
  • Spectral responses
  • Vaccine informatics

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology


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