The changing face of head and neck cancer in the 21st century: The impact of hpv on the epidemiology and pathology of oral cancer

William H. Westra

doi:10.1007/s12105-009-0100-y

The changing face of head and neck cancer in the 21st century: The impact of hpv on the epidemiology and pathology of oral cancer

William H. Westra

Research output: Contribution to journal › Article › peer-review

190 Scopus citations

Abstract

The longstanding notion that head and neck squamous cell carcinoma (HNSCC) is a uniform disease process is changing. Divergence in epidemiologic trends among HNSCCs arising in different anatomic subsites has introduced a view that HNSCC is a heterogeneous group. Analysis of molecular genetic changes discloses not just individual tumor differences, but also consistent large-scale differences that permit the recognition of important tumor subtypes. One recently recognized subtype is the human papillomavirus (HPV)-positive oropharyngeal carcinoma. HPV-positive oropharyngeal cancer now dominates the head and neck oncology landscape, and its escalating incidence is impacting on diagnostic, preventive and therapeutic practices.

Original language	English (US)
Pages (from-to)	78-81
Number of pages	4
Journal	Head and Neck Pathology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1007/s12105-009-0100-y
State	Published - Mar 2009
Externally published	Yes

Keywords

Head and neck squamous cell carcinoma
Human papillomavirus
In situ hybridization
Oral cancer

ASJC Scopus subject areas

Pathology and Forensic Medicine
Otorhinolaryngology
Oncology

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10.1007/s12105-009-0100-y

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The changing face of head and neck cancer in the 21st century: The impact of hpv on the epidemiology and pathology of oral cancer

Abstract

Keywords

ASJC Scopus subject areas

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