The challenge of polypharmacy in an aging population and implications for future antiretroviral therapy development

Janessa M. Smith; Charles Williams Flexner

doi:10.1097/QAD.0000000000001401

The challenge of polypharmacy in an aging population and implications for future antiretroviral therapy development

Janessa M. Smith, Charles Williams Flexner

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

It is estimated that by 2030 nearly three-quarters of persons living with HIV will be 50 years and older. The aging HIV population presents a new clinical concern for HIV providers: adverse effects from polypharmacy. An aging population means more comorbidities and potentially more drug-drug interactions for providers to manage. This review discusses major comorbidities including cardiovascular disease, anticoagulation, hypertension, diabetes mellitus and malignancy and considerations for drug-interactions with antiretrovirals.

Original language	English (US)
Pages (from-to)	S173-S184
Journal	AIDS
Volume	31
DOIs	https://doi.org/10.1097/QAD.0000000000001401
State	Published - Jun 1 2017

Keywords

aging
antiretroviral therapy
drug interactions

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/QAD.0000000000001401

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abstract = "It is estimated that by 2030 nearly three-quarters of persons living with HIV will be 50 years and older. The aging HIV population presents a new clinical concern for HIV providers: adverse effects from polypharmacy. An aging population means more comorbidities and potentially more drug-drug interactions for providers to manage. This review discusses major comorbidities including cardiovascular disease, anticoagulation, hypertension, diabetes mellitus and malignancy and considerations for drug-interactions with antiretrovirals.",

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AB - It is estimated that by 2030 nearly three-quarters of persons living with HIV will be 50 years and older. The aging HIV population presents a new clinical concern for HIV providers: adverse effects from polypharmacy. An aging population means more comorbidities and potentially more drug-drug interactions for providers to manage. This review discusses major comorbidities including cardiovascular disease, anticoagulation, hypertension, diabetes mellitus and malignancy and considerations for drug-interactions with antiretrovirals.

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KW - drug interactions

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The challenge of polypharmacy in an aging population and implications for future antiretroviral therapy development

Abstract

Keywords

ASJC Scopus subject areas

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