@article{13ca240acfb044c6a98a33ee92aa3062,
title = "The “central vein sign” in inflammatory demyelination: The role of fibrillar collagen type I",
abstract = "Accumulating evidence corroborates the role of the “central vein sign” in the radiological diagnosis of multiple sclerosis (MS). Here, we report human magnetic resonance imaging (MRI) and corresponding pathological data that inflammation-dependent intracerebral remodeling of the vessel wall is directly associated with the prominence of intralesional veins on susceptibility-based MRI. In adult marmosets with experimental autoimmune encephalomyelitis, vessel-wall fibrosis was detected early in the demyelinating process, even in lesions <2 weeks old, though fibrosis was more evident after 6 weeks. Vascular remodeling consisted of both luminal enlargement and eccentric thickening of the perivascular space (fibrillar collagen type I deposition) and affected almost exclusively white matter, but not subpial cortical, lesions. The long-term effect of vessel remodeling in MS lesions is currently unknown, but it might potentially affect tissue repair. ANN NEUROL 2019;85:934–942.",
author = "Martina Absinta and Govind Nair and Monaco, {Maria Chiara G.} and Dragan Maric and Lee, {Nathanael J.} and Ha, {Seung Kwon} and Luciano, {Nicholas J.} and Pascal Sati and Steven Jacobson and Reich, {Daniel S.}",
note = "Funding Information: The Intramural Research Program of the National Institute of Neurological Disorders and Stroke supported this study. Dr Absinta is also supported by the National Multiple Sclerosis Society (NMSS; Grant No.: FG 2093-A-1) and the Conrad N. Hilton Foundation (Grant No.: 17313). The Human Brain Collection Core (HBCC; National Institute of Mental Health's (NIMH) Division of Intramural Programs) provided human brain control tissue. We thank Dr Afonso C. Silva (NIH/NINDS) for the help with marmoset EAE projects and Dr Eugene Major (NIH/NINDS) for providing the neural progenitor cell line. Funding Information: Dr Daniel S. Reich received research support from collaborations with the Myelin Repair Foundation, Vertex Pharmaceuticals, and the Adelson Medical Research Foundation, unrelated to the present study. Funding Information: The Intramural Research Program of the National Institute of Neurological Disorders and Stroke supported this study. Dr Absinta is also supported by the National Multiple Sclerosis Society (NMSS; Grant No.: FG 2093-A-1) Funding Information: and the Conrad N. Hilton Foundation (Grant No.: 17313). The Human Brain Collection Core (HBCC; National Institute of Mental Health{\textquoteright}s (NIMH) Division of Intramural Programs) provided human brain control tissue. Publisher Copyright: Published 2019. This article is a U.S. Government work and is in the public domain in the USA.",
year = "2019",
month = jun,
doi = "10.1002/ana.25461",
language = "English (US)",
volume = "85",
pages = "934--942",
journal = "Annals of neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "6",
}