The catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia

Faith B. Dickerson; John J. Boronow; Cassie Stallings; Andrea E. Origoni; Anne Sullens; Robert H. Yolken

doi:10.1016/j.schres.2007.05.021

The catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia

Faith B. Dickerson, John J. Boronow, Cassie Stallings, Andrea E. Origoni, Anne Sullens, Robert H. Yolken

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: A valine/methionine polymorphism of the catechol O-methyltransferase gene at the nucleotide which encodes amino acid val or met at position 158 in the protein (COMT Val158Met polymorphism) has been associated with deficits in executive functioning in schizophrenia in some studies. The association between the COMT polymorphism and other cognitive domains has been the focus of only limited investigation. Methods: We measured COMT Val158Met genotypes in N = 364 individuals with schizophrenia. Cognitive functioning was assessed with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We employed univariate and multivariate analyses of variance to determine the association between COMT genotypes and the RBANS index and individual test scores. Results: There was no significant association between the COMT Val158Met genotypes and any of the RBANS index or individual test scores measured in either univariate or multivariate analyses (all p > .3). Conclusion: Based on the results in our sample, the catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia.

Original language	English (US)
Pages (from-to)	87-92
Number of pages	6
Journal	Schizophrenia Research
Volume	96
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2007.05.021
State	Published - Nov 2007

Keywords

COMT
Cognition
Genetic
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2007.05.021

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title = "The catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia",

abstract = "Background: A valine/methionine polymorphism of the catechol O-methyltransferase gene at the nucleotide which encodes amino acid val or met at position 158 in the protein (COMT Val158Met polymorphism) has been associated with deficits in executive functioning in schizophrenia in some studies. The association between the COMT polymorphism and other cognitive domains has been the focus of only limited investigation. Methods: We measured COMT Val158Met genotypes in N = 364 individuals with schizophrenia. Cognitive functioning was assessed with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We employed univariate and multivariate analyses of variance to determine the association between COMT genotypes and the RBANS index and individual test scores. Results: There was no significant association between the COMT Val158Met genotypes and any of the RBANS index or individual test scores measured in either univariate or multivariate analyses (all p > .3). Conclusion: Based on the results in our sample, the catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia.",

keywords = "COMT, Cognition, Genetic, Schizophrenia",

author = "Dickerson, {Faith B.} and Boronow, {John J.} and Cassie Stallings and Origoni, {Andrea E.} and Anne Sullens and Yolken, {Robert H.}",

note = "Funding Information: Funding for this study was provided by the Stanley Medical Research Institute (SMRI). SMRI had no further role in study design, in the collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the paper for publication. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2007",

month = nov,

doi = "10.1016/j.schres.2007.05.021",

language = "English (US)",

volume = "96",

pages = "87--92",

journal = "Schizophrenia Research",

issn = "0920-9964",

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T1 - The catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia

AU - Dickerson, Faith B.

AU - Boronow, John J.

AU - Stallings, Cassie

AU - Origoni, Andrea E.

AU - Sullens, Anne

AU - Yolken, Robert H.

N1 - Funding Information: Funding for this study was provided by the Stanley Medical Research Institute (SMRI). SMRI had no further role in study design, in the collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the paper for publication. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2007/11

Y1 - 2007/11

N2 - Background: A valine/methionine polymorphism of the catechol O-methyltransferase gene at the nucleotide which encodes amino acid val or met at position 158 in the protein (COMT Val158Met polymorphism) has been associated with deficits in executive functioning in schizophrenia in some studies. The association between the COMT polymorphism and other cognitive domains has been the focus of only limited investigation. Methods: We measured COMT Val158Met genotypes in N = 364 individuals with schizophrenia. Cognitive functioning was assessed with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We employed univariate and multivariate analyses of variance to determine the association between COMT genotypes and the RBANS index and individual test scores. Results: There was no significant association between the COMT Val158Met genotypes and any of the RBANS index or individual test scores measured in either univariate or multivariate analyses (all p > .3). Conclusion: Based on the results in our sample, the catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia.

AB - Background: A valine/methionine polymorphism of the catechol O-methyltransferase gene at the nucleotide which encodes amino acid val or met at position 158 in the protein (COMT Val158Met polymorphism) has been associated with deficits in executive functioning in schizophrenia in some studies. The association between the COMT polymorphism and other cognitive domains has been the focus of only limited investigation. Methods: We measured COMT Val158Met genotypes in N = 364 individuals with schizophrenia. Cognitive functioning was assessed with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We employed univariate and multivariate analyses of variance to determine the association between COMT genotypes and the RBANS index and individual test scores. Results: There was no significant association between the COMT Val158Met genotypes and any of the RBANS index or individual test scores measured in either univariate or multivariate analyses (all p > .3). Conclusion: Based on the results in our sample, the catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia.

KW - COMT

KW - Cognition

KW - Genetic

KW - Schizophrenia

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The catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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