The cancer stem cell phenotype: You can't win until you learn how to lose it

Hernando Lopez-Bertoni; John Laterra

doi:10.4161/23723556.2014.989760

The cancer stem cell phenotype: You can't win until you learn how to lose it

Hernando Lopez-Bertoni, John Laterra

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Cancer stem cells and their relatively differentiated progenitors coexist in dynamic equilibrium and are subject to bidirectional conversion. We recently showed that reprogramming transcription factors induce glioblastoma cells to become stem-like and tumor propagating via a mechanism involving changes in global DNA methylation and downregulation of miRNAs.

Original language	English (US)
Article number	e989760
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/23723556.2014.989760
State	Published - Jul 3 2015

Keywords

DNA methylation
cancer stem cell
miRNAs
reprogramming transcription factors
tumorigenesis

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.4161/23723556.2014.989760

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title = "The cancer stem cell phenotype: You can't win until you learn how to lose it",

abstract = "Cancer stem cells and their relatively differentiated progenitors coexist in dynamic equilibrium and are subject to bidirectional conversion. We recently showed that reprogramming transcription factors induce glioblastoma cells to become stem-like and tumor propagating via a mechanism involving changes in global DNA methylation and downregulation of miRNAs.",

keywords = "DNA methylation, cancer stem cell, miRNAs, reprogramming transcription factors, tumorigenesis",

author = "Hernando Lopez-Bertoni and John Laterra",

note = "Funding Information: This work was supported by NIH grants NS076759 (JL) and NS073611 (JL). Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2015, {\textcopyright} Hernando Lopez-Bertoni and John Laterra.",

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AU - Laterra, John

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N2 - Cancer stem cells and their relatively differentiated progenitors coexist in dynamic equilibrium and are subject to bidirectional conversion. We recently showed that reprogramming transcription factors induce glioblastoma cells to become stem-like and tumor propagating via a mechanism involving changes in global DNA methylation and downregulation of miRNAs.

AB - Cancer stem cells and their relatively differentiated progenitors coexist in dynamic equilibrium and are subject to bidirectional conversion. We recently showed that reprogramming transcription factors induce glioblastoma cells to become stem-like and tumor propagating via a mechanism involving changes in global DNA methylation and downregulation of miRNAs.

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KW - cancer stem cell

KW - miRNAs

KW - reprogramming transcription factors

KW - tumorigenesis

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The cancer stem cell phenotype: You can't win until you learn how to lose it

Abstract

Keywords

ASJC Scopus subject areas

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