Abstract
The K variant of the butyrylcholinesterase gene (BChE) was recently found to occur at an increased frequency in a late onset Alzheimer's disease (AD) population, specifically in individuals carrying the ε4 allele of the apolipoprotein E (APOE) gene. This suggested synergy between these two genes resulting in an increased risk of late-onset AD. We have genotyped 62 community-based and 329 clinic-based AD cases, and 201 community-based controls at BChE and APOE and find no independent association between BChE and AD nor interaction with APOE in risk for AD in either our clinic or community-based samples.
Original language | English (US) |
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Pages (from-to) | 115-118 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 249 |
Issue number | 2-3 |
DOIs | |
State | Published - Jun 19 1998 |
Externally published | Yes |
Keywords
- Alzheimer's Disease
- Apolipoprotein E
- Butyrylcholinesterase
- Genetic association
- K variant
ASJC Scopus subject areas
- General Neuroscience