The brain map of gait variability in aging, cognitive impairment and dementia—A systematic review

Qu Tian, Nathalie Chastan, Woei Nan Bair, Susan M. Resnick, Luigi Ferrucci, Stephanie A. Studenski

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


While gait variability may reflect subtle changes due to aging or cognitive impairment (CI), associated brain characteristics remain unclear. We summarize structural and functional neuroimaging findings associated with gait variability in older adults with and without CI and dementia. We identified 17 eligible studies; all were cross-sectional; few examined multiple brain areas. In older adults, temporal gait variability was associated with structural differences in medial areas important for lower limb coordination and balance. Both temporal and spatial gait variability were associated with structural and functional differences in hippocampus and primary sensorimotor cortex and structural differences in anterior cingulate cortex, basal ganglia, association tracts, and posterior thalamic radiation. In CI or dementia, some associations were found in primary motor cortex, hippocampus, prefrontal cortex and basal ganglia. In older adults, gait variability may be associated with areas important for sensorimotor integration and coordination. To comprehend the neural basis of gait variability with aging and CI, longitudinal studies of multiple brain areas are needed.

Original languageEnglish (US)
Pages (from-to)149-162
Number of pages14
JournalNeuroscience and Biobehavioral Reviews
StatePublished - Mar 1 2017
Externally publishedYes


  • Aging
  • Cognitive impairment
  • Dementia
  • Gait variability
  • Neuroimaging
  • Older adults

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


Dive into the research topics of 'The brain map of gait variability in aging, cognitive impairment and dementia—A systematic review'. Together they form a unique fingerprint.

Cite this