The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology

Lukas Pezawas; Beth A. Verchinski; Venkata S. Mattay; Joseph H. Callicott; Bhaskar S. Kolachana; Richard E. Straub; Michael F. Egan; Andreas Meyer-Lindenberg; Daniel R. Weinberger

doi:10.1523/JNEUROSCI.2680-04.2004

The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology

Lukas Pezawas, Beth A. Verchinski, Venkata S. Mattay, Joseph H. Callicott, Bhaskar S. Kolachana, Richard E. Straub, Michael F. Egan, Andreas Meyer-Lindenberg, Daniel R. Weinberger

Research output: Contribution to journal › Article › peer-review

708 Scopus citations

Abstract

A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.

Original language	English (US)
Pages (from-to)	10099-10102
Number of pages	4
Journal	Journal of Neuroscience
Volume	24
Issue number	45
DOIs	https://doi.org/10.1523/JNEUROSCI.2680-04.2004
State	Published - Nov 10 2004
Externally published	Yes

Keywords

Alzheimer
BDNF
Down syndrome
Gene
Huntington
Imaging genomics
Memory
Morphometry
Neurotrophic
Schizophrenia
VBM
Voxel-based

ASJC Scopus subject areas

Neuroscience(all)

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10.1523/JNEUROSCI.2680-04.2004

Cite this

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title = "The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology",

abstract = "A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.",

keywords = "Alzheimer, BDNF, Down syndrome, Gene, Huntington, Imaging genomics, Memory, Morphometry, Neurotrophic, Schizophrenia, VBM, Voxel-based",

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AU - Pezawas, Lukas

AU - Verchinski, Beth A.

AU - Mattay, Venkata S.

AU - Callicott, Joseph H.

AU - Kolachana, Bhaskar S.

AU - Straub, Richard E.

AU - Egan, Michael F.

AU - Meyer-Lindenberg, Andreas

AU - Weinberger, Daniel R.

PY - 2004/11/10

Y1 - 2004/11/10

N2 - A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.

AB - A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.

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KW - BDNF

KW - Down syndrome

KW - Gene

KW - Huntington

KW - Imaging genomics

KW - Memory

KW - Morphometry

KW - Neurotrophic

KW - Schizophrenia

KW - VBM

KW - Voxel-based

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The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology

Abstract

Keywords

ASJC Scopus subject areas

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