The bone marrow microenvironment and leukemia: Biology and therapeutic targeting

Edward Allan R. Sison; Patrick Brown

doi:10.1586/ehm.11.30

The bone marrow microenvironment and leukemia: Biology and therapeutic targeting

Edward Allan R. Sison, Patrick Brown

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

Multiple studies have demonstrated that interaction with the bone marrow stromal microenvironment contributes to the survival of leukemia cells. One explanation for this phenomenon is the interaction between the cell surface receptors CXCR4 and CXCL12. Through CXCL12/CXCR4-mediated chemotaxis, leukemia cells migrate to microscopic niches within the bone marrow, which leads to increased proliferation and survival. Several studies have suggested that increased CXCR4 expression may portend a poor prognosis in various types of leukemia, possibly due to increased protection of leukemia cells by bone marrow stroma. A potential therapeutic strategy to overcome this stromal-mediated survival advantage is to target CXCR4. Inhibition of CXCR4 may allow leukemia cells to be released from bone marrow niches that confer resistance to chemotherapy and negate the survival benefit imparted by bone marrow stroma.

Original language	English (US)
Pages (from-to)	271-283
Number of pages	13
Journal	Expert review of hematology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1586/ehm.11.30
State	Published - Jun 2011
Externally published	Yes

Keywords

ALL
AMD3100
AML
BKT140
CXCL12
CXCR4
SDF-1
TN14003
microenvironment
plerixafor

ASJC Scopus subject areas

Hematology

Access to Document

10.1586/ehm.11.30

Cite this

@article{6fe13900e2f04121ab552a4413b3e5ef,

title = "The bone marrow microenvironment and leukemia: Biology and therapeutic targeting",

abstract = "Multiple studies have demonstrated that interaction with the bone marrow stromal microenvironment contributes to the survival of leukemia cells. One explanation for this phenomenon is the interaction between the cell surface receptors CXCR4 and CXCL12. Through CXCL12/CXCR4-mediated chemotaxis, leukemia cells migrate to microscopic niches within the bone marrow, which leads to increased proliferation and survival. Several studies have suggested that increased CXCR4 expression may portend a poor prognosis in various types of leukemia, possibly due to increased protection of leukemia cells by bone marrow stroma. A potential therapeutic strategy to overcome this stromal-mediated survival advantage is to target CXCR4. Inhibition of CXCR4 may allow leukemia cells to be released from bone marrow niches that confer resistance to chemotherapy and negate the survival benefit imparted by bone marrow stroma.",

keywords = "ALL, AMD3100, AML, BKT140, CXCL12, CXCR4, SDF-1, TN14003, microenvironment, plerixafor",

author = "Sison, {Edward Allan R.} and Patrick Brown",

note = "Funding Information: Pat Brown and Edward Allan R Sison sare supported by funding from NIH grants K23CA111728 and T32CA060441, respectively. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",

year = "2011",

month = jun,

doi = "10.1586/ehm.11.30",

language = "English (US)",

volume = "4",

pages = "271--283",

journal = "Expert review of hematology",

issn = "1747-4086",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

TY - JOUR

T1 - The bone marrow microenvironment and leukemia

T2 - Biology and therapeutic targeting

AU - Sison, Edward Allan R.

AU - Brown, Patrick

N1 - Funding Information: Pat Brown and Edward Allan R Sison sare supported by funding from NIH grants K23CA111728 and T32CA060441, respectively. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PY - 2011/6

Y1 - 2011/6

N2 - Multiple studies have demonstrated that interaction with the bone marrow stromal microenvironment contributes to the survival of leukemia cells. One explanation for this phenomenon is the interaction between the cell surface receptors CXCR4 and CXCL12. Through CXCL12/CXCR4-mediated chemotaxis, leukemia cells migrate to microscopic niches within the bone marrow, which leads to increased proliferation and survival. Several studies have suggested that increased CXCR4 expression may portend a poor prognosis in various types of leukemia, possibly due to increased protection of leukemia cells by bone marrow stroma. A potential therapeutic strategy to overcome this stromal-mediated survival advantage is to target CXCR4. Inhibition of CXCR4 may allow leukemia cells to be released from bone marrow niches that confer resistance to chemotherapy and negate the survival benefit imparted by bone marrow stroma.

AB - Multiple studies have demonstrated that interaction with the bone marrow stromal microenvironment contributes to the survival of leukemia cells. One explanation for this phenomenon is the interaction between the cell surface receptors CXCR4 and CXCL12. Through CXCL12/CXCR4-mediated chemotaxis, leukemia cells migrate to microscopic niches within the bone marrow, which leads to increased proliferation and survival. Several studies have suggested that increased CXCR4 expression may portend a poor prognosis in various types of leukemia, possibly due to increased protection of leukemia cells by bone marrow stroma. A potential therapeutic strategy to overcome this stromal-mediated survival advantage is to target CXCR4. Inhibition of CXCR4 may allow leukemia cells to be released from bone marrow niches that confer resistance to chemotherapy and negate the survival benefit imparted by bone marrow stroma.

KW - ALL

KW - AMD3100

KW - AML

KW - BKT140

KW - CXCL12

KW - CXCR4

KW - SDF-1

KW - TN14003

KW - microenvironment

KW - plerixafor

UR - http://www.scopus.com/inward/record.url?scp=79959274113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959274113&partnerID=8YFLogxK

U2 - 10.1586/ehm.11.30

DO - 10.1586/ehm.11.30

M3 - Review article

C2 - 21668393

AN - SCOPUS:79959274113

SN - 1747-4086

VL - 4

SP - 271

EP - 283

JO - Expert review of hematology

JF - Expert review of hematology

IS - 3

ER -

The bone marrow microenvironment and leukemia: Biology and therapeutic targeting

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this