The BNT162b2 mRNA Vaccine Elicits Robust Humoral and Cellular Immune Responses in People Living with Human Immunodeficiency Virus (HIV)

Bezawit A. Woldemeskel; Andrew H. Karaba; Caroline C. Garliss; Evan J. Beck; Kristy H. Wang; Oliver Laeyendecker; Andrea L. Cox; Joel N. Blankson

doi:10.1093/cid/ciab648

The BNT162b2 mRNA Vaccine Elicits Robust Humoral and Cellular Immune Responses in People Living with Human Immunodeficiency Virus (HIV)

Bezawit A. Woldemeskel
, Andrew H. Karaba
, Caroline C. Garliss
, Evan J. Beck
, Kristy H. Wang
, Oliver Laeyendecker
, Andrea L. Cox
, Joel N. Blankson

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Previous studies have shown that certain vaccines induce suboptimal responses in people living with human immunodeficiency virus (HIV, PLWH). However, responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have not been fully characterized in these patients. Here we show that the BNT162b2 vaccine induces robust immune responses comparable to responses in healthy donors.

Original language	English (US)
Pages (from-to)	1268-1270
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	74
Issue number	7
DOIs	https://doi.org/10.1093/cid/ciab648
State	Published - Apr 1 2022

Keywords

COVID
PLWH
SARS-CoV-2
mRNA vaccine

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1093/cid/ciab648

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title = "The BNT162b2 mRNA Vaccine Elicits Robust Humoral and Cellular Immune Responses in People Living with Human Immunodeficiency Virus (HIV)",

abstract = "Previous studies have shown that certain vaccines induce suboptimal responses in people living with human immunodeficiency virus (HIV, PLWH). However, responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have not been fully characterized in these patients. Here we show that the BNT162b2 vaccine induces robust immune responses comparable to responses in healthy donors.",

keywords = "COVID, PLWH, SARS-CoV-2, mRNA vaccine",

author = "Woldemeskel, \{Bezawit A.\} and Karaba, \{Andrew H.\} and Garliss, \{Caroline C.\} and Beck, \{Evan J.\} and Wang, \{Kristy H.\} and Oliver Laeyendecker and Cox, \{Andrea L.\} and Blankson, \{Joel N.\}",

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doi = "10.1093/cid/ciab648",

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AU - Woldemeskel, Bezawit A.

AU - Karaba, Andrew H.

AU - Garliss, Caroline C.

AU - Beck, Evan J.

AU - Wang, Kristy H.

AU - Laeyendecker, Oliver

AU - Cox, Andrea L.

AU - Blankson, Joel N.

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Previous studies have shown that certain vaccines induce suboptimal responses in people living with human immunodeficiency virus (HIV, PLWH). However, responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have not been fully characterized in these patients. Here we show that the BNT162b2 vaccine induces robust immune responses comparable to responses in healthy donors.

AB - Previous studies have shown that certain vaccines induce suboptimal responses in people living with human immunodeficiency virus (HIV, PLWH). However, responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have not been fully characterized in these patients. Here we show that the BNT162b2 vaccine induces robust immune responses comparable to responses in healthy donors.

KW - COVID

KW - PLWH

KW - SARS-CoV-2

KW - mRNA vaccine

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UR - https://www.scopus.com/pages/publications/85128487308#tab=citedBy

U2 - 10.1093/cid/ciab648

DO - 10.1093/cid/ciab648

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 7

ER -

The BNT162b2 mRNA Vaccine Elicits Robust Humoral and Cellular Immune Responses in People Living with Human Immunodeficiency Virus (HIV)

Abstract

Keywords

ASJC Scopus subject areas

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