@inbook{b784b0b87f8449979040d3b3b7d396a9,
title = "The Biology of Gangliosides",
abstract = "Gangliosides comprise a varied family of glycosphingolipid structures bearing one or more sialic acid residues. They are found in all mammalian tissues but are most abundant in the brain, where they represent the quantitatively major class of sialoglycans. As prominent molecular determinants on cell surfaces, they function as molecular-recognition partners for diverse glycan-binding proteins ranging from bacterial toxins to endogenous cell–cell adhesion molecules. Gangliosides also regulate the activity of plasma membrane proteins, including protein tyrosine kinases, by lateral association in the same membranes in which they reside. Their roles in molecular recognition and membrane protein regulation implicate gangliosides in human physiology and pathology, including infectious diseases, diabetes, cancer, and neurodegeneration. The varied structures and biosynthetic pathways of gangliosides are presented here, along with representative examples of their biological functions in health and disease.",
keywords = "Alzheimer's disease, Bacterial toxins, Insulin receptor, Intellectual disability, Myelin-associated glycoprotein, Peripheral neuropathy",
author = "Schnaar, {Ronald L.}",
note = "Funding Information: The author thanks the many authors of the recently published book “ Gangliosides in Health and Disease ” 137 for providing a wealth of information about ganglioside biology. The author's efforts are supported in part by a grant from the National Institute of Mental Health, National Institutes of Health, U. S. A. (MH107695). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = jan,
day = "1",
doi = "10.1016/bs.accb.2018.09.002",
language = "English (US)",
isbn = "9780128171479",
series = "Advances in Carbohydrate Chemistry and Biochemistry",
publisher = "Academic Press Inc.",
pages = "113--148",
editor = "Baker, {David C.}",
booktitle = "Sialic Acids, Part II",
}