The Biology of Aging and Frailty

Research output: Contribution to journalReview articlepeer-review

153 Scopus citations


In developing and validating the concept of frailty as a geriatric syndrome, it has been necessary to distinguish the clinical expression of frailty from normal age-related changes and other age-related disease pathologies. A framework for excluding potentially confounding disease and a working clinical tool to diagnose frailty have been provided. The associations between frailty and other pathophysiologies has also been shown. However, investigating the underlying biologic basis for the geriatric syndrome of frailty by studying basic homeostatic pathways and mechanisms has not proceeded at the same rate. The following article provides an overview of the homeostatic pathways emphasized in research on aging and explains how this science may help to stimulate frailty research.

Original languageEnglish (US)
Pages (from-to)27-37
Number of pages11
JournalClinics in geriatric medicine
Issue number1
StatePublished - Feb 2011


  • Aging
  • Apoptosis
  • Frailty
  • Inflammation
  • Senescence

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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