TY - GEN
T1 - The biologic scaffold immune microenvironment inhibits tumor formation and synergizes with immunotherapy
AU - Wolf, Matthew T.
AU - Ganguly, Sudipto
AU - Narain, Radhika
AU - Sadtler, Kaitlyn
AU - Pardoll, Drew M.
AU - Elisseeff, Jennifer H.
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Tissue engineering scaffolds are designed to create an environment that encourages tissue growth. However, many of the same processes and cells involved in tissue healing are associated with tumor progression, including immune cells. Cancer immunotherapy attempts to reverse tumor escape from immune clearance, but requires a responsive tumor microenvironment. It is currently unknown whether a pro-regenerative scaffold immune environment influences cancer progression or cancer immunotherapy. Biologic scaffolds prepared from decellularized tissues are at the crossroads of tissue engineering and surgical oncology as they aid in surgical reconstruction after tumor resection. We sought to determine the elements of a biologic scaffold immune microenvironment that affect tumor formation and cancer immunotherapy responses.
AB - Statement of Purpose: Tissue engineering scaffolds are designed to create an environment that encourages tissue growth. However, many of the same processes and cells involved in tissue healing are associated with tumor progression, including immune cells. Cancer immunotherapy attempts to reverse tumor escape from immune clearance, but requires a responsive tumor microenvironment. It is currently unknown whether a pro-regenerative scaffold immune environment influences cancer progression or cancer immunotherapy. Biologic scaffolds prepared from decellularized tissues are at the crossroads of tissue engineering and surgical oncology as they aid in surgical reconstruction after tumor resection. We sought to determine the elements of a biologic scaffold immune microenvironment that affect tumor formation and cancer immunotherapy responses.
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M3 - Conference contribution
AN - SCOPUS:85065394831
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 233
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -