The biochemical diagnosis of acromegaly: revising the role of measurement of IGF-I and GH after glucose load in 5 questions

Rosa Maria Paragliola, Cinzia Carrozza, Salvatore M. Corsello, Roberto Salvatori

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Acromegaly is a rare disorder characterized by the excessive secretion of growth hormone (GH), mostly caused by pituitary adenomas. While in full-blown cases the diagnosis is easy to establish, milder cases are more challenging. Additionally, establishing whether full cure after surgery is reached may be difficult. Areas covered: In this article, we will review the challenges posed by the variability in measurements of GH and its main effector insulin-like growth factor I (IGF-I) due to both biological changes, co-morbidities, and assays variability. Expert opinion: Interpretation of GH and IGF-I assays is important in establishing an early diagnosis of acromegaly, in avoiding misdiagnosis, and in establishing if cure is achieved by surgery. Physicians should be familiar with the variables that affect measurements of these 2 hormones, and with the performance of the assays available in their practice.

Original languageEnglish (US)
Pages (from-to)205-224
Number of pages20
JournalExpert Review of Endocrinology and Metabolism
Volume17
Issue number3
DOIs
StatePublished - 2022

Keywords

  • Acromegaly
  • IGF-I
  • binding proteins
  • body mass index
  • competitive assay
  • growth hormone
  • sandwich assay

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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