TY - JOUR
T1 - The basolateral amygdala mediates the effects of cues associated with meal interruption on feeding behavior
AU - Galarce, Ezequiel M.
AU - McDannald, Michael A.
AU - Holland, Peter C.
N1 - Funding Information:
This research was supported by NIMH grants MH53667 and MH65879 .
PY - 2010/9/2
Y1 - 2010/9/2
N2 - Considerable evidence shows that environmental cues that signal food delivery when rats are food-deprived can substantially potentiate feeding later when rats are food-sated. Similarly, cues associated with meal interruption, food removal or impending food scarcity may also induce increased eating. For example, after learning the association between a discrete " interruption" stimulus and the unexpected termination of food trials, sated rats show enhanced food consumption when exposed to that stimulus. In Experiment 1, unlike sham-lesioned controls, rats with bilateral excitotoxic lesions of the basolateral amygdala (BLA) failed to display such cue-potentiated feeding. In Experiment 2, potentiation of feeding by an interruption signal was found to be food-specific. That is, a stimulus that signaled interruption of trials with one food but not trials with a second food later only facilitated consumption of the first food. These studies extend our knowledge of the psychological and neural processes underlying cue-induced feeding. Understanding these mechanisms may contribute our understanding of the etiology and treatment of binge eating disorders.
AB - Considerable evidence shows that environmental cues that signal food delivery when rats are food-deprived can substantially potentiate feeding later when rats are food-sated. Similarly, cues associated with meal interruption, food removal or impending food scarcity may also induce increased eating. For example, after learning the association between a discrete " interruption" stimulus and the unexpected termination of food trials, sated rats show enhanced food consumption when exposed to that stimulus. In Experiment 1, unlike sham-lesioned controls, rats with bilateral excitotoxic lesions of the basolateral amygdala (BLA) failed to display such cue-potentiated feeding. In Experiment 2, potentiation of feeding by an interruption signal was found to be food-specific. That is, a stimulus that signaled interruption of trials with one food but not trials with a second food later only facilitated consumption of the first food. These studies extend our knowledge of the psychological and neural processes underlying cue-induced feeding. Understanding these mechanisms may contribute our understanding of the etiology and treatment of binge eating disorders.
KW - Amygdala
KW - Bingeing
KW - Conditioning
KW - Cue-potentiated feeding
KW - Scarcity
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U2 - 10.1016/j.brainres.2010.02.042
DO - 10.1016/j.brainres.2010.02.042
M3 - Article
C2 - 20171956
AN - SCOPUS:77956170189
SN - 0006-8993
VL - 1350
SP - 112
EP - 122
JO - Brain research
JF - Brain research
ER -