Abstract
Associations of mean glucose and time in range (70-180 mg/dL) from continuous glucose monitoring (CGM) with HbA1c in adults with type 2 diabetes are not well characterized. We conducted a secondary analysis of 186 participants from the Hyperglycemic Profiles in Obstructive Sleep Apnea (HYPNOS) trial. Participants simultaneously wore Dexcom G4 and Abbott Libre Pro CGM sensors up to 4 weeks. Mean HbA1c was 7.7% (SD, 1.3). There were strong negative Pearson's correlations of HbA1c with CGM time in range (-0.79, Abbott; -0.81, Dexcom) and strong positive correlations with CGM mean glucose (Dexcom, 0.84; Abbott, 0.82). However, there were large differences in CGM mean glucose (±20 mg/dL) and time in range (±14%) at any given HbA1c value. Mean glucose and HbA1c are strongly correlated in type 2 diabetes patients not taking insulin but discordance is evident at the individual level. Clinicians should expect discordance and use HbA1c and CGM in a complementary manner. ClinicalTrials.gov
Original language | English (US) |
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Pages (from-to) | 86-90 |
Number of pages | 5 |
Journal | Diabetes Technology and Therapeutics |
Volume | 25 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2023 |
Keywords
- Continuous glucose monitoring
- HbA1c
- Mean glucose
- Type 2 diabetes
- Variability
ASJC Scopus subject areas
- Medical Laboratory Technology
- Endocrinology
- Endocrinology, Diabetes and Metabolism