The Associations of Mean Glucose and Time in Range from Continuous Glucose Monitoring with HbA1c in Adults with Type 2 Diabetes

Elizabeth Selvin, Dan Wang, Mary R. Rooney, Justin Echouffo-Tcheugui, Michael Fang, Scott Zeger, Joseph Sartini, Olive Tang, Josef Coresh, R. Nisha Aurora, Naresh M. Punjabi

Research output: Contribution to journalArticlepeer-review

Abstract

Associations of mean glucose and time in range (70-180 mg/dL) from continuous glucose monitoring (CGM) with HbA1c in adults with type 2 diabetes are not well characterized. We conducted a secondary analysis of 186 participants from the Hyperglycemic Profiles in Obstructive Sleep Apnea (HYPNOS) trial. Participants simultaneously wore Dexcom G4 and Abbott Libre Pro CGM sensors up to 4 weeks. Mean HbA1c was 7.7% (SD, 1.3). There were strong negative Pearson's correlations of HbA1c with CGM time in range (-0.79, Abbott; -0.81, Dexcom) and strong positive correlations with CGM mean glucose (Dexcom, 0.84; Abbott, 0.82). However, there were large differences in CGM mean glucose (±20 mg/dL) and time in range (±14%) at any given HbA1c value. Mean glucose and HbA1c are strongly correlated in type 2 diabetes patients not taking insulin but discordance is evident at the individual level. Clinicians should expect discordance and use HbA1c and CGM in a complementary manner. ClinicalTrials.gov

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalDiabetes Technology and Therapeutics
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2023

Keywords

  • Continuous glucose monitoring
  • HbA1c
  • Mean glucose
  • Type 2 diabetes
  • Variability

ASJC Scopus subject areas

  • Medical Laboratory Technology
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Fingerprint

Dive into the research topics of 'The Associations of Mean Glucose and Time in Range from Continuous Glucose Monitoring with HbA1c in Adults with Type 2 Diabetes'. Together they form a unique fingerprint.

Cite this