The association of selected cancers with service in the US Military in Vietnam I. Non-Hodgkin's lymphoma

Edward A. Brann; Anthony S. Fowler; David S. Freedman; Judith R. Qualters; W. Dana Flanders; Coleen A. Boyle; Marion R. Nadel; Marcie Jo Kresnow; Andrew L. Baughman; Elizabeth A. Cochran; Sandra S. Emrich; Martha I. Hunter; Karen S. Colberg; Pierre DeCoufle; Robert J. Delaney; J. David Erickson; Melinda L. Flock; Marilyn L. Kirk; Peter M. Layde; Brenda R. Mitchell; Peter J. McCumiskey; Philip H. Rhodes; Raymond S. Greenberg; Ralph J. Coates; Helen R. Gregory; Wong Ho Chow; W. Douglas Thompson; Martha B. DeGrand; Leon F. Burmeister; Nyla J. Logsden-Sackett; George Everett; Stephanie F. VanLier; Frederick F. Holmes; Cathy D. Boysen; Marianna K. Baum; William A. Raub; Hilda M. Greenberg; Robert R. Levine; John E. Davies; Donald F. Austin; Judy Goldstein; Margaret H. Hackett; Samuel D. Kaplan; Glenda Farrell; Judith Woolridge Jenkins; William A. Satariano; Amy R. Juntunen; Donna Swanson; Mary H. Dupuis; Thomas L. Vaughan; Berta Nicol-Blades; Linda Heuser; Carl R. Kjeldsberg; Thomas V. Colby; Ronald L. Weiss; David R. Head; Reuben S. Doggett; Bruce D. Ragsdale; Edward B. Chung; William B. Dupree; John R. Craig; Gary C. Kanel; Sugantha Govindarajan; Robert R. Peters; Hugh R. Edmondson; John Boitnott; Douglas R. Gnepp; Charles A. Waldron; Walter C. Bauer

The association of selected cancers with service in the US Military in Vietnam I. Non-Hodgkin's lymphoma

Edward A. Brann, Anthony S. Fowler, David S. Freedman, Judith R. Qualters, W. Dana Flanders, Coleen A. Boyle, Marion R. Nadel, Marcie Jo Kresnow, Andrew L. Baughman, Elizabeth A. Cochran, Sandra S. Emrich, Martha I. Hunter, Karen S. Colberg, Pierre DeCoufle, Robert J. Delaney, J. David Erickson, Melinda L. Flock, Marilyn L. Kirk, Peter M. Layde, Brenda R. MitchellPeter J. McCumiskey, Philip H. Rhodes, Raymond S. Greenberg, Ralph J. Coates, Helen R. Gregory, Wong Ho Chow, W. Douglas Thompson, Martha B. DeGrand, Leon F. Burmeister, Nyla J. Logsden-Sackett, George Everett, Stephanie F. VanLier, Frederick F. Holmes, Cathy D. Boysen, Marianna K. Baum, William A. Raub, Hilda M. Greenberg, Robert R. Levine, John E. Davies, Donald F. Austin, Judy Goldstein, Margaret H. Hackett, Samuel D. Kaplan, Glenda Farrell, Judith Woolridge Jenkins, William A. Satariano, Amy R. Juntunen, Donna Swanson, Mary H. Dupuis, Thomas L. Vaughan, Berta Nicol-Blades, Linda Heuser, Carl R. Kjeldsberg, Thomas V. Colby, Ronald L. Weiss, David R. Head, Reuben S. Doggett, Bruce D. Ragsdale, Edward B. Chung, William B. Dupree, John R. Craig, Gary C. Kanel, Sugantha Govindarajan, Robert R. Peters, Hugh R. Edmondson, John Boitnott, Douglas R. Gnepp, Charles A. Waldron, Walter C. Bauer

Research output: Contribution to journal › Article › peer-review

Abstract

As part of a series of investigations into the health of Vietnam veterans, we conducted a population-based, case-control study of non-Hodgkin's lymphoma between 1984 and 1988. All men born between 1929 and 1953 and diagnosed as having non-Hodgkin's lymphoma in an area covered by eight cancer registries were considered eligible. Control subjects were identified by random-digit dialing from these same regions and were frequency-matched to men with lymphoma by age. Analyses of 1157 men with pathologically confirmed lymphomas and 1776 control subjects showed that the risk of non-Hodgkin's lymphoma was approximately 50% higher among Vietnam veterans (odds ratio, 1.47;95% confidence interval, 1.1 to 2.0) compared with men who did not serve in Vietnam. Vietnam veterans were also at higher risk relative to (1) men who had not served in the military, (2) other veterans, and (3) other veterans who served between 1964 and 1972. An analysis of the military histories of the 232 Vietnam veterans suggested that the relative risk (1) increased with length of service in Vietnam (P = .10), and (2) was higher among men in the sea-based Navy than among other veterans (P = .11). Little difference in risk, however, was noted according to dates of service, type of unit, military region, or any other characteristics that may have been associated with the use of Agent Orange. Although the cause remains uncertain, results of this study indicate that the risk of non-Hodgkin's lymphoma is higher among Vietnam veterans than among other men.

Original language	English (US)
Pages (from-to)	2473-2483
Number of pages	11
Journal	Archives of internal medicine
Volume	150
Issue number	12
State	Published - Dec 1990
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine

Cite this

Brann, E. A., Fowler, A. S., Freedman, D. S., Qualters, J. R., Flanders, W. D., Boyle, C. A., Nadel, M. R., Kresnow, M. J., Baughman, A. L., Cochran, E. A., Emrich, S. S., Hunter, M. I., Colberg, K. S., DeCoufle, P., Delaney, R. J., Erickson, J. D., Flock, M. L., Kirk, M. L., Layde, P. M., ... Bauer, W. C. (1990). The association of selected cancers with service in the US Military in Vietnam I. Non-Hodgkin's lymphoma. Archives of internal medicine, 150(12), 2473-2483.

Brann, EA, Fowler, AS, Freedman, DS, Qualters, JR, Flanders, WD, Boyle, CA, Nadel, MR, Kresnow, MJ, Baughman, AL, Cochran, EA, Emrich, SS, Hunter, MI, Colberg, KS, DeCoufle, P, Delaney, RJ, Erickson, JD, Flock, ML, Kirk, ML, Layde, PM, Mitchell, BR, McCumiskey, PJ, Rhodes, PH, Greenberg, RS, Coates, RJ, Gregory, HR, Chow, WH, Douglas Thompson, W, DeGrand, MB, Burmeister, LF, Logsden-Sackett, NJ, Everett, G, VanLier, SF, Holmes, FF, Boysen, CD, Baum, MK, Raub, WA, Greenberg, HM, Levine, RR, Davies, JE, Austin, DF, Goldstein, J, Hackett, MH, Kaplan, SD, Farrell, G, Jenkins, JW, Satariano, WA, Juntunen, AR, Swanson, D, Dupuis, MH, Vaughan, TL, Nicol-Blades, B, Heuser, L, Kjeldsberg, CR, Colby, TV, Weiss, RL, Head, DR, Doggett, RS, Ragsdale, BD, Chung, EB, Dupree, WB, Craig, JR, Kanel, GC, Govindarajan, S, Peters, RR, Edmondson, HR, Boitnott, J, Gnepp, DR, Waldron, CA & Bauer, WC 1990, 'The association of selected cancers with service in the US Military in Vietnam I. Non-Hodgkin's lymphoma', Archives of internal medicine, vol. 150, no. 12, pp. 2473-2483.

@article{55d014b09e494b0092a1964d4a39b543,

title = "The association of selected cancers with service in the US Military in Vietnam I. Non-Hodgkin's lymphoma",

abstract = "As part of a series of investigations into the health of Vietnam veterans, we conducted a population-based, case-control study of non-Hodgkin's lymphoma between 1984 and 1988. All men born between 1929 and 1953 and diagnosed as having non-Hodgkin's lymphoma in an area covered by eight cancer registries were considered eligible. Control subjects were identified by random-digit dialing from these same regions and were frequency-matched to men with lymphoma by age. Analyses of 1157 men with pathologically confirmed lymphomas and 1776 control subjects showed that the risk of non-Hodgkin's lymphoma was approximately 50% higher among Vietnam veterans (odds ratio, 1.47;95% confidence interval, 1.1 to 2.0) compared with men who did not serve in Vietnam. Vietnam veterans were also at higher risk relative to (1) men who had not served in the military, (2) other veterans, and (3) other veterans who served between 1964 and 1972. An analysis of the military histories of the 232 Vietnam veterans suggested that the relative risk (1) increased with length of service in Vietnam (P = .10), and (2) was higher among men in the sea-based Navy than among other veterans (P = .11). Little difference in risk, however, was noted according to dates of service, type of unit, military region, or any other characteristics that may have been associated with the use of Agent Orange. Although the cause remains uncertain, results of this study indicate that the risk of non-Hodgkin's lymphoma is higher among Vietnam veterans than among other men.",

author = "Brann, {Edward A.} and Fowler, {Anthony S.} and Freedman, {David S.} and Qualters, {Judith R.} and Flanders, {W. Dana} and Boyle, {Coleen A.} and Nadel, {Marion R.} and Kresnow, {Marcie Jo} and Baughman, {Andrew L.} and Cochran, {Elizabeth A.} and Emrich, {Sandra S.} and Hunter, {Martha I.} and Colberg, {Karen S.} and Pierre DeCoufle and Delaney, {Robert J.} and Erickson, {J. David} and Flock, {Melinda L.} and Kirk, {Marilyn L.} and Layde, {Peter M.} and Mitchell, {Brenda R.} and McCumiskey, {Peter J.} and Rhodes, {Philip H.} and Greenberg, {Raymond S.} and Coates, {Ralph J.} and Gregory, {Helen R.} and Chow, {Wong Ho} and {Douglas Thompson}, W. and DeGrand, {Martha B.} and Burmeister, {Leon F.} and Logsden-Sackett, {Nyla J.} and George Everett and VanLier, {Stephanie F.} and Holmes, {Frederick F.} and Boysen, {Cathy D.} and Baum, {Marianna K.} and Raub, {William A.} and Greenberg, {Hilda M.} and Levine, {Robert R.} and Davies, {John E.} and Austin, {Donald F.} and Judy Goldstein and Hackett, {Margaret H.} and Kaplan, {Samuel D.} and Glenda Farrell and Jenkins, {Judith Woolridge} and Satariano, {William A.} and Juntunen, {Amy R.} and Donna Swanson and Dupuis, {Mary H.} and Vaughan, {Thomas L.} and Berta Nicol-Blades and Linda Heuser and Kjeldsberg, {Carl R.} and Colby, {Thomas V.} and Weiss, {Ronald L.} and Head, {David R.} and Doggett, {Reuben S.} and Ragsdale, {Bruce D.} and Chung, {Edward B.} and Dupree, {William B.} and Craig, {John R.} and Kanel, {Gary C.} and Sugantha Govindarajan and Peters, {Robert R.} and Edmondson, {Hugh R.} and John Boitnott and Gnepp, {Douglas R.} and Waldron, {Charles A.} and Bauer, {Walter C.}",

year = "1990",

month = dec,

language = "English (US)",

volume = "150",

pages = "2473--2483",

journal = "Archives of internal medicine",

issn = "0003-9926",

publisher = "American Medical Association",

number = "12",

}

TY - JOUR

T1 - The association of selected cancers with service in the US Military in Vietnam I. Non-Hodgkin's lymphoma

AU - Brann, Edward A.

AU - Fowler, Anthony S.

AU - Freedman, David S.

AU - Qualters, Judith R.

AU - Flanders, W. Dana

AU - Boyle, Coleen A.

AU - Nadel, Marion R.

AU - Kresnow, Marcie Jo

AU - Baughman, Andrew L.

AU - Cochran, Elizabeth A.

AU - Emrich, Sandra S.

AU - Hunter, Martha I.

AU - Colberg, Karen S.

AU - DeCoufle, Pierre

AU - Delaney, Robert J.

AU - Erickson, J. David

AU - Flock, Melinda L.

AU - Kirk, Marilyn L.

AU - Layde, Peter M.

AU - Mitchell, Brenda R.

AU - McCumiskey, Peter J.

AU - Rhodes, Philip H.

AU - Greenberg, Raymond S.

AU - Coates, Ralph J.

AU - Gregory, Helen R.

AU - Chow, Wong Ho

AU - Douglas Thompson, W.

AU - DeGrand, Martha B.

AU - Burmeister, Leon F.

AU - Logsden-Sackett, Nyla J.

AU - Everett, George

AU - VanLier, Stephanie F.

AU - Holmes, Frederick F.

AU - Boysen, Cathy D.

AU - Baum, Marianna K.

AU - Raub, William A.

AU - Greenberg, Hilda M.

AU - Levine, Robert R.

AU - Davies, John E.

AU - Austin, Donald F.

AU - Goldstein, Judy

AU - Hackett, Margaret H.

AU - Kaplan, Samuel D.

AU - Farrell, Glenda

AU - Jenkins, Judith Woolridge

AU - Satariano, William A.

AU - Juntunen, Amy R.

AU - Swanson, Donna

AU - Dupuis, Mary H.

AU - Vaughan, Thomas L.

AU - Nicol-Blades, Berta

AU - Heuser, Linda

AU - Kjeldsberg, Carl R.

AU - Colby, Thomas V.

AU - Weiss, Ronald L.

AU - Head, David R.

AU - Doggett, Reuben S.

AU - Ragsdale, Bruce D.

AU - Chung, Edward B.

AU - Dupree, William B.

AU - Craig, John R.

AU - Kanel, Gary C.

AU - Govindarajan, Sugantha

AU - Peters, Robert R.

AU - Edmondson, Hugh R.

AU - Boitnott, John

AU - Gnepp, Douglas R.

AU - Waldron, Charles A.

AU - Bauer, Walter C.

PY - 1990/12

Y1 - 1990/12

N2 - As part of a series of investigations into the health of Vietnam veterans, we conducted a population-based, case-control study of non-Hodgkin's lymphoma between 1984 and 1988. All men born between 1929 and 1953 and diagnosed as having non-Hodgkin's lymphoma in an area covered by eight cancer registries were considered eligible. Control subjects were identified by random-digit dialing from these same regions and were frequency-matched to men with lymphoma by age. Analyses of 1157 men with pathologically confirmed lymphomas and 1776 control subjects showed that the risk of non-Hodgkin's lymphoma was approximately 50% higher among Vietnam veterans (odds ratio, 1.47;95% confidence interval, 1.1 to 2.0) compared with men who did not serve in Vietnam. Vietnam veterans were also at higher risk relative to (1) men who had not served in the military, (2) other veterans, and (3) other veterans who served between 1964 and 1972. An analysis of the military histories of the 232 Vietnam veterans suggested that the relative risk (1) increased with length of service in Vietnam (P = .10), and (2) was higher among men in the sea-based Navy than among other veterans (P = .11). Little difference in risk, however, was noted according to dates of service, type of unit, military region, or any other characteristics that may have been associated with the use of Agent Orange. Although the cause remains uncertain, results of this study indicate that the risk of non-Hodgkin's lymphoma is higher among Vietnam veterans than among other men.

AB - As part of a series of investigations into the health of Vietnam veterans, we conducted a population-based, case-control study of non-Hodgkin's lymphoma between 1984 and 1988. All men born between 1929 and 1953 and diagnosed as having non-Hodgkin's lymphoma in an area covered by eight cancer registries were considered eligible. Control subjects were identified by random-digit dialing from these same regions and were frequency-matched to men with lymphoma by age. Analyses of 1157 men with pathologically confirmed lymphomas and 1776 control subjects showed that the risk of non-Hodgkin's lymphoma was approximately 50% higher among Vietnam veterans (odds ratio, 1.47;95% confidence interval, 1.1 to 2.0) compared with men who did not serve in Vietnam. Vietnam veterans were also at higher risk relative to (1) men who had not served in the military, (2) other veterans, and (3) other veterans who served between 1964 and 1972. An analysis of the military histories of the 232 Vietnam veterans suggested that the relative risk (1) increased with length of service in Vietnam (P = .10), and (2) was higher among men in the sea-based Navy than among other veterans (P = .11). Little difference in risk, however, was noted according to dates of service, type of unit, military region, or any other characteristics that may have been associated with the use of Agent Orange. Although the cause remains uncertain, results of this study indicate that the risk of non-Hodgkin's lymphoma is higher among Vietnam veterans than among other men.

UR - http://www.scopus.com/inward/record.url?scp=0025630447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025630447&partnerID=8YFLogxK

M3 - Article

C2 - 2244764

AN - SCOPUS:0025630447

SN - 0003-9926

VL - 150

SP - 2473

EP - 2483

JO - Archives of internal medicine

JF - Archives of internal medicine

IS - 12

ER -

The association of selected cancers with service in the US Military in Vietnam I. Non-Hodgkin's lymphoma

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this