TY - JOUR
T1 - The association of multidimensional sleep health with adiposity in heart failure with preserved ejection fraction
AU - Polanka, Brittanny M.
AU - Yanek, Lisa R.
AU - Hays, Allison G.
AU - Sharma, Kavita
AU - Shah, Sanjiv J.
AU - St-Onge, Marie Pierre
AU - Ouyang, Pamela
AU - Mathews, Lena
N1 - Funding Information:
Funding was provided by the American Heart Association Strategic Collaborative Grant Award No: 18SCG34320007 and Strategically Focused Research Network Center Grant Award Nos: 16SFRN27880000 and 16SFRN28780016. Dr. Polanka acknowledges support by NIH/NHLBI (T32HL007779–28). Dr. Hays is partially supported by NIH/NHLBI (R01HL147660). Dr. St-Onge is partially supported by NIH/NHLBI (R35HL155670). Dr. Shah is supported by NIH/NHLBI (U54HL160273 R01HL107577, R01HL140731, R01HL149423). Dr. Mathews acknowledges support by the Johns Hopkins Clinician Scientist Award.
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Background: There are bi-directional relationships between sleep disturbances and obesity, both of which are prevalent in patients with heart failure with preserved ejection fraction (HFpEF). However, little is known about the sleep-obesity association in HFpEF. Objectives: To determine associations of multidimensional sleep health, night movement, sleep fragmentation, and sleep-disordered breathing (SDB) risk with overall and regional adiposity in HFpEF patients. Methods: Men and women with HFpEF (n = 49) were assessed via 14-day actigraphy, Pittsburgh Sleep Quality Index, and Epworth Sleepiness Scale to derive multidimensional sleep health. SDB risk was assessed via Berlin Questionnaire. Body composition was measured using anthropometry; MRI quantification of epicardial, abdominal, liver, and thigh adipose tissue was performed in a subsample (n = 22). Spearman correlation (rs) and linear regression analyses (β coefficient) were used to estimate bivariate and age-adjusted associations. Results: Multidimensional sleep health was inversely associated with BMI (rs = -0.50, p < .001; unadjusted: β = -4.00, 95%CI: -5.87, -2.13; age-adjusted: β = -2.48, 95%CI: -4.65, -0.30), thigh subcutaneous adipose tissue (rs = -0.50, p = .018; unadjusted: β = -36.95, 95%CI: -67.31, -6.59), and thigh intermuscular fat (age-adjusted: β = -0.24, 95%CI: -0.48, -0.01). Night movement and sleep fragmentation were associated with greater intermuscular thigh and lower liver fat. High SDB risk was associated with a higher visceral-to-subcutaneous ratio of abdominal adiposity and lower thigh adiposity. Conclusions: Adverse multidimensional sleep health is associated with higher adiposity measures in HFpEF patients. Further studies are needed to determine whether intervening on sleep could ameliorate excess adiposity or whether weight loss could improve sleep quality in HFpEF.
AB - Background: There are bi-directional relationships between sleep disturbances and obesity, both of which are prevalent in patients with heart failure with preserved ejection fraction (HFpEF). However, little is known about the sleep-obesity association in HFpEF. Objectives: To determine associations of multidimensional sleep health, night movement, sleep fragmentation, and sleep-disordered breathing (SDB) risk with overall and regional adiposity in HFpEF patients. Methods: Men and women with HFpEF (n = 49) were assessed via 14-day actigraphy, Pittsburgh Sleep Quality Index, and Epworth Sleepiness Scale to derive multidimensional sleep health. SDB risk was assessed via Berlin Questionnaire. Body composition was measured using anthropometry; MRI quantification of epicardial, abdominal, liver, and thigh adipose tissue was performed in a subsample (n = 22). Spearman correlation (rs) and linear regression analyses (β coefficient) were used to estimate bivariate and age-adjusted associations. Results: Multidimensional sleep health was inversely associated with BMI (rs = -0.50, p < .001; unadjusted: β = -4.00, 95%CI: -5.87, -2.13; age-adjusted: β = -2.48, 95%CI: -4.65, -0.30), thigh subcutaneous adipose tissue (rs = -0.50, p = .018; unadjusted: β = -36.95, 95%CI: -67.31, -6.59), and thigh intermuscular fat (age-adjusted: β = -0.24, 95%CI: -0.48, -0.01). Night movement and sleep fragmentation were associated with greater intermuscular thigh and lower liver fat. High SDB risk was associated with a higher visceral-to-subcutaneous ratio of abdominal adiposity and lower thigh adiposity. Conclusions: Adverse multidimensional sleep health is associated with higher adiposity measures in HFpEF patients. Further studies are needed to determine whether intervening on sleep could ameliorate excess adiposity or whether weight loss could improve sleep quality in HFpEF.
KW - Adiposity
KW - Heart failure with preserved ejection fraction
KW - Multidimensional sleep health
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85143981951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85143981951&partnerID=8YFLogxK
U2 - 10.1016/j.hrtlng.2022.12.005
DO - 10.1016/j.hrtlng.2022.12.005
M3 - Article
C2 - 36516532
AN - SCOPUS:85143981951
SN - 0147-9563
VL - 58
SP - 144
EP - 151
JO - Heart and Lung
JF - Heart and Lung
ER -