TY - JOUR
T1 - The association between personality and plasma biomarkers of astrogliosis and neuronal injury
AU - Terracciano, Antonio
AU - Walker, Keenan
AU - An, Yang
AU - Luchetti, Martina
AU - Stephan, Yannick
AU - Moghekar, Abhay R.
AU - Sutin, Angelina R.
AU - Ferrucci, Luigi
AU - Resnick, Susan M.
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2023/8
Y1 - 2023/8
N2 - Personality traits have been associated with the risk of dementia and Alzheimer's disease neuropathology, including amyloid and tau. This study examines whether personality traits are concurrently related to plasma glial fibrillary acidic protein (GFAP), a marker of astrogliosis, and neurofilament light (NfL), a marker of neuronal injury. Cognitively unimpaired participants from the Baltimore Longitudinal Study on Aging (N = 786; age: 22–95) were assayed for plasma GFAP and NfL and completed the Revised NEO Personality Inventory, which measures 5 domains and 30 facets of personality. Neuroticism (particularly vulnerability to stress, anxiety, and depression) was associated with higher GFAP and NfL. Conscientiousness was associated with lower GFAP. Extraversion (particularly positive emotions, assertiveness, and activity) was related to lower GFAP and NfL. These associations were independent of demographic, behavioral, and health covariates and not moderated by age, sex, or apolipoprotein E genotype. The personality correlates of astrogliosis and neuronal injury tend to be similar, are found in individuals without cognitive impairment, and point to potential neurobiological underpinnings of the association between personality traits and neurodegenerative diseases.
AB - Personality traits have been associated with the risk of dementia and Alzheimer's disease neuropathology, including amyloid and tau. This study examines whether personality traits are concurrently related to plasma glial fibrillary acidic protein (GFAP), a marker of astrogliosis, and neurofilament light (NfL), a marker of neuronal injury. Cognitively unimpaired participants from the Baltimore Longitudinal Study on Aging (N = 786; age: 22–95) were assayed for plasma GFAP and NfL and completed the Revised NEO Personality Inventory, which measures 5 domains and 30 facets of personality. Neuroticism (particularly vulnerability to stress, anxiety, and depression) was associated with higher GFAP and NfL. Conscientiousness was associated with lower GFAP. Extraversion (particularly positive emotions, assertiveness, and activity) was related to lower GFAP and NfL. These associations were independent of demographic, behavioral, and health covariates and not moderated by age, sex, or apolipoprotein E genotype. The personality correlates of astrogliosis and neuronal injury tend to be similar, are found in individuals without cognitive impairment, and point to potential neurobiological underpinnings of the association between personality traits and neurodegenerative diseases.
KW - Alzheimer's disease
KW - Astrogliosis
KW - Glial fibrillary acidic protein
KW - Neurodegeneration
KW - Neurofilament light
KW - Personality
KW - Plasma biomarkers
UR - http://www.scopus.com/inward/record.url?scp=85159632743&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85159632743&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2023.04.011
DO - 10.1016/j.neurobiolaging.2023.04.011
M3 - Article
C2 - 37210782
AN - SCOPUS:85159632743
SN - 0197-4580
VL - 128
SP - 65
EP - 73
JO - Neurobiology of aging
JF - Neurobiology of aging
ER -