@article{36fb1dfb4721461d91d7010acfb2e5da,
title = "The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism",
abstract = "Advanced parental age is a well-replicated risk factor for autism spectrum disorder (ASD), a neurodevelopmental condition with a complex and not well-defined etiology. We sought to determine parental age associations with ASD-related outcomes in subjects at high familial risk for ASD. A total of 397 younger siblings of a child with ASD, drawn from existing prospective high familial risk cohorts, were included in these analyses. Overall, we did not observe significant associations of advanced parental age with clinical ASD diagnosis, Social Responsiveness Scale, or Vineland Adaptive Behavior Scales scores. Instead, increased odds of ASD were found with paternal age < 30 years (adjusted odds ratio [AOR] = 2.83 and 95% confidence intervals [CI] = 1.14–7.02). Likewise, younger age (<30 years) for both parents was associated with decreases in Mullen Scales of Early Learning early learning composite (MSEL-ELC) scores (adjusted β = −9.62, 95% CI = −17.1 to −2.15). We also found significant increases in cognitive functioning based on MSEL-ELC scores with increasing paternal age (adjusted β associated with a 10-year increase in paternal age = 5.51, 95% CI = 0.70–10.3). Results suggest the potential for a different relationship between parental age and ASD-related outcomes in families with elevated ASD risk than has been observed in general population samples. Autism Res 2020, 13: 998-1010.",
keywords = "autism, autism-related traits, high familial risk, parental age",
author = "Kristen Lyall and Lanxin Song and Kelly Botteron and Croen, {Lisa A.} and Dager, {Stephen R.} and Fallin, {M. Daniele} and Hazlett, {Heather C.} and Elizabeth Kauffman and Rebecca Landa and Christine Ladd-Acosta and Messinger, {Daniel S.} and Sally Ozonoff and Juhi Pandey and Joseph Piven and Schmidt, {Rebecca J.} and Schultz, {Robert T.} and Stone, {Wendy L.} and Newschaffer, {Craig J.} and Volk, {Heather E.}",
note = "Funding Information: This work was supported by Environmental Influences on Child Health Outcomes (ECHO) grant number UH3OD023342 (Newschaffer). The EARLI Study was funded by the National Institute of Environmental Health Sciences, the National Institute of Mental Health, the National Institute of Child Health and Human Development, and the National Institute of Neurologic Disease and Stroke (R01 ES016443), with additional funding from Autism Speaks (AS 5938). The MARBLES Study has been supported by NIH grants: P01-ES011269, 1R01-ES020392, R01-ES025574, P30-ES023513, and R01-ES028089 from the National Institute of Environmental Health Sciences; U54-HD079125 from the Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Centers Network; NIH-UL1-TR000002 for the UC Davis Clinical and Translational Sciences Center and 2K12-HD051958; by the following U.S. EPA (U.S. Environmental Protection Agency) grants #R-829388 and R833292; by DOD #AR110194; and by the UC Davis MIND Institute. The BSRC sites included in this work were funded by grants 2R01 MH068398 (Ozonoff) from the National Institute of Mental Health, R01HD057284 (Messinger and Stone) from the National Institute of Child Health and Human Development (NICHD), and grant R01MH059630 (Landa) from the National Institute of Mental Health. The Infant Brain Imaging Study (IBIS) Network is an NIH funded Autism Centers of Excellence project and consists of a consortium of eight universities in the United States and Canada. IBIS is funded by R01-HD055741 and R01-HD055741-S1 (Piven) from National Institute of Child Health and Human Development (NICHD). Funding Information: This work was supported by Environmental Influences on Child Health Outcomes (ECHO) grant number UH3OD023342 (Newschaffer). The EARLI Study was funded by the National Institute of Environmental Health Sciences, the National Institute of Mental Health, the National Institute of Child Health and Human Development, and the National Institute of Neurologic Disease and Stroke (R01 ES016443), with additional funding from Autism Speaks (AS 5938). The MARBLES Study has been supported by NIH grants: P01‐ES011269, 1R01‐ES020392, R01‐ES025574, P30‐ES023513, and R01‐ES028089 from the National Institute of Environmental Health Sciences; U54‐HD079125 from the Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Centers Network; NIH‐UL1‐TR000002 for the UC Davis Clinical and Translational Sciences Center and 2K12‐HD051958; by the following U.S. EPA (U.S. Environmental Protection Agency) grants #R‐829388 and R833292; by DOD #AR110194; and by the UC Davis MIND Institute. The BSRC sites included in this work were funded by grants 2R01 MH068398 (Ozonoff) from the National Institute of Mental Health, R01HD057284 (Messinger and Stone) from the National Institute of Child Health and Human Development (NICHD), and grant R01MH059630 (Landa) from the National Institute of Mental Health. The Infant Brain Imaging Study (IBIS) Network is an NIH funded Autism Centers of Excellence project and consists of a consortium of eight universities in the United States and Canada. IBIS is funded by R01‐HD055741 and R01‐HD055741‐S1 (Piven) from National Institute of Child Health and Human Development (NICHD). Publisher Copyright: {\textcopyright} 2020 International Society for Autism Research, Wiley Periodicals, Inc.",
year = "2020",
month = jun,
day = "1",
doi = "10.1002/aur.2303",
language = "English (US)",
volume = "13",
pages = "998--1010",
journal = "Autism Research",
issn = "1939-3792",
publisher = "John Wiley and Sons Inc.",
number = "6",
}