TY - JOUR
T1 - The Association between Multiparity and Adipokine Levels
T2 - The Multi-Ethnic Study of Atherosclerosis
AU - Rodriguez, Carla P.
AU - Ogunmoroti, Oluseye
AU - Quispe, Renato
AU - Osibogun, Olatokunbo
AU - Ndumele, Chiadi E.
AU - Echouffo Tcheugui, Justin
AU - Minhas, Anum S.
AU - Bertoni, Alain G.
AU - Allison, Matthew A.
AU - Michos, Erin D.
N1 - Funding Information:
C.P.R. and E.D.M. designed the study and wrote the initial draft. O. Ogunmoroti performed the statistical analysis. M.A.A. secured grant funding for the measurement of adipokines and visceral fat by CT. R.Q., O. Ogunmoroti and O. Osibogun, C.E.N., J.E.T., A.S.M., A.G.B., and M.A.A. all provided critical revisions for important intellectual content. All authors approved of the final draft for submission.
Publisher Copyright:
© Copyright 2022, Mary Ann Liebert, Inc., publishers 2022.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Background: Multiparity is a risk factor for cardiovascular disease (CVD). However, the mechanisms of this relationship are unknown. Adipokines may predispose multiparous women to certain cardiometabolic complications that can increase their risk of future CVD. Materials and Methods: We studied 973 female participants of the Multi-Ethnic Study of Atherosclerosis free of CVD, who had complete data on parity and adipokines measured at Examination 2 or 3 (randomly assigned). Parity was categorized as nulliparity, 1-2, 3-4, and ?5 live births. Multivariable linear regression was used to evaluate the association of parity with leptin, resistin, and adiponectin levels. Results: The women had mean age of 65 ± 9 years. After adjustment for age, race/ethnicity, study site, education, menopause status, smoking, physical activity, use of hormone therapy, and waist circumference, a history of grand multiparity (?5 live births) was associated with 11% higher resistin levels (95% confidence interval [CI] 0-23) and 3-4 live births was associated with 23% higher leptin levels (95% CI 7-42), compared with nulliparity. After adjustment for computed tomography-measured visceral fat, the association of 3-4 live births with leptin remained significant. There were no significant associations of parity with adipokines after further adjustment for additional CVD risk factors. Multigravidity (but not parity) was inversely associated with adiponectin levels. Conclusions: In a multiethnic cohort of women, greater parity was associated with resistin and leptin; however, this association was attenuated after accounting for CVD risk factors. Dysregulation of adipokines could contribute to the excess CVD risk associated with multiparity. Further studies are needed to determine whether adipokines independently mediate the relationship between multiparity and CVD. Clinical trials registration: The MESA cohort is registered at NCT00005487.
AB - Background: Multiparity is a risk factor for cardiovascular disease (CVD). However, the mechanisms of this relationship are unknown. Adipokines may predispose multiparous women to certain cardiometabolic complications that can increase their risk of future CVD. Materials and Methods: We studied 973 female participants of the Multi-Ethnic Study of Atherosclerosis free of CVD, who had complete data on parity and adipokines measured at Examination 2 or 3 (randomly assigned). Parity was categorized as nulliparity, 1-2, 3-4, and ?5 live births. Multivariable linear regression was used to evaluate the association of parity with leptin, resistin, and adiponectin levels. Results: The women had mean age of 65 ± 9 years. After adjustment for age, race/ethnicity, study site, education, menopause status, smoking, physical activity, use of hormone therapy, and waist circumference, a history of grand multiparity (?5 live births) was associated with 11% higher resistin levels (95% confidence interval [CI] 0-23) and 3-4 live births was associated with 23% higher leptin levels (95% CI 7-42), compared with nulliparity. After adjustment for computed tomography-measured visceral fat, the association of 3-4 live births with leptin remained significant. There were no significant associations of parity with adipokines after further adjustment for additional CVD risk factors. Multigravidity (but not parity) was inversely associated with adiponectin levels. Conclusions: In a multiethnic cohort of women, greater parity was associated with resistin and leptin; however, this association was attenuated after accounting for CVD risk factors. Dysregulation of adipokines could contribute to the excess CVD risk associated with multiparity. Further studies are needed to determine whether adipokines independently mediate the relationship between multiparity and CVD. Clinical trials registration: The MESA cohort is registered at NCT00005487.
KW - adipokines
KW - adiposity
KW - parity
KW - risk factors
KW - women
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UR - http://www.scopus.com/inward/citedby.url?scp=85130637776&partnerID=8YFLogxK
U2 - 10.1089/jwh.2021.0091
DO - 10.1089/jwh.2021.0091
M3 - Article
C2 - 34747649
AN - SCOPUS:85130637776
SN - 1540-9996
VL - 31
SP - 741
EP - 749
JO - Journal of Women's Health
JF - Journal of Women's Health
IS - 5
ER -