The association between hantavirus infection and selenium deficiency in mainland China

Li Qun Fang, Marco Goeijenbier, Shu Qing Zuo, Li Ping Wang, S. Liang, Sabra L. Klein, Xin Lou Li, Kun Liu, Lu Liang, Peng Gong, Gregory E. Glass, Eric van Gorp, Jan H. Richardus, Jia Qi Ma, Wu Chun Cao, Sake J. de Vlas

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses and transmitted by rodents is a significant public health problem in China, and occurs more frequently in selenium-deficient regions. To study the role of selenium concentration in HFRS incidence we used a multidisciplinary approach combining ecological analysis with preliminary experimental data. The incidence of HFRS in humans was about six times higher in severe selenium-deficient and double in moderate deficient areas compared to non-deficient areas. This association became statistically stronger after correction for other significant environment-related factors (low elevation, few grasslands, or an abundance of forests) and was independent of geographical scale by separate analyses for different climate regions. A case-control study of HFRS patients admitted to the hospital revealed increased activity and plasma levels of selenium binding proteins while selenium supplementation in vitro decreased viral replication in an endothelial cell model after infection with a low multiplicity of infection (MOI). Viral replication with a higher MOI was not affected by selenium supplementation. Our findings indicate that selenium deficiency may contribute to an increased prevalence of hantavirus infections in both humans and rodents. Future studies are needed to further examine the exact mechanism behind this observation before selenium supplementation in deficient areas could be implemented for HFRS prevention.

Original languageEnglish (US)
Pages (from-to)333-351
Number of pages19
Issue number1
StatePublished - Jan 20 2015


  • China
  • Environmental factors
  • Hantavirus
  • Hemorrhagic fever with renal syndrome
  • Rodents
  • Selenium

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


Dive into the research topics of 'The association between hantavirus infection and selenium deficiency in mainland China'. Together they form a unique fingerprint.

Cite this