The anopheles innate immune system in the defense against malaria infection

April M. Clayton, Yuemei Dong, George Dimopoulos

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations


The multifaceted innate immune system of insects is capable of fighting infection by a variety of pathogens including those causing human malaria. Malaria transmission by the Anopheles mosquito depends on the Plasmodium parasite's successful completion of its lifecycle in the insect vector, a process that involves interactions with several tissues and cell types as well as with the mosquito's innate immune system. This review will discuss our current understanding of the Anopheles mosquito's innate immune responses against the malaria parasite Plasmodium and the influence of the insect's intestinal microbiota on parasite infection.

Original languageEnglish (US)
Pages (from-to)169-181
Number of pages13
JournalJournal of Innate Immunity
Issue number2
StatePublished - Feb 2014


  • Anopheles
  • Innate immunity
  • Malaria
  • Mosquito
  • Plasmodium

ASJC Scopus subject areas

  • Immunology and Allergy


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