The anatomy and physiology of the sinoatrial node-A contemporary review

Oliver Monfredi; Halina Dobrzynski; Tapas Mondal; Mark R. Boyett; Gwilym M. Morris

doi:10.1111/j.1540-8159.2010.02838.x

The anatomy and physiology of the sinoatrial node-A contemporary review

Oliver Monfredi, Halina Dobrzynski, Tapas Mondal, Mark R. Boyett, Gwilym M. Morris

Research output: Contribution to journal › Review article › peer-review

Abstract

The sinoatrial node is the primary pacemaker of the heart. Nodal dysfunction with aging, heart failure, atrial fibrillation, and even endurance athletic training can lead to a wide variety of pathological clinical syndromes. Recent work utilizing molecular markers to map the extent of the node, along with the delineation of a novel paranodal area intermediate in characteristics between the node and the surrounding atrial muscle, has shown that pacemaker tissue is more widely spread in the right atrium than previously appreciated. This can explain the phenomenon of a "wandering pacemaker" and concomitant changes in the P-wave morphology. Extensive knowledge now exists regarding the molecular architecture of the node (in particular, the expression of ion channels) and how this relates to pacemaking. This review is an up-to-date summary of the current state of our appreciation of the above topics.

Original language	English (US)
Pages (from-to)	1392-1406
Number of pages	15
Journal	PACE - Pacing and Clinical Electrophysiology
Volume	33
Issue number	11
DOIs	https://doi.org/10.1111/j.1540-8159.2010.02838.x
State	Published - Nov 2010
Externally published	Yes

Keywords

electrophysiology
ion channels
pacemaking
sinoatrial node

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1111/j.1540-8159.2010.02838.x

Cite this

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The anatomy and physiology of the sinoatrial node-A contemporary review

Abstract

Keywords

ASJC Scopus subject areas

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