TY - JOUR
T1 - The anaemia of cancer
T2 - Death by a thousand cuts
AU - Spivak, Jerry L.
PY - 2005/7
Y1 - 2005/7
N2 - Cancer has a negative systemic impact on its host in addition to its local or metastatic effects, and no cancer complication is more ubiquitous than anaemia, a condition for which there is now a specific remedy, the recombinant growth factor erythropoietin. This is not a trivial therapeutic consideration, because cancer-associated anaemia has an adverse influence on survival regardless of tumour type. However, the pharmacological correction of anaemia with recombinant erythropoietin could promote tumour growth, whereas the use of tumour-necrosis factor-α (TNFα) and TNF-related apoptosis-inducing ligand as antitumour agents could exacerbate anaemia, thereby perpetuating tissue hypoxia and tumour progression.
AB - Cancer has a negative systemic impact on its host in addition to its local or metastatic effects, and no cancer complication is more ubiquitous than anaemia, a condition for which there is now a specific remedy, the recombinant growth factor erythropoietin. This is not a trivial therapeutic consideration, because cancer-associated anaemia has an adverse influence on survival regardless of tumour type. However, the pharmacological correction of anaemia with recombinant erythropoietin could promote tumour growth, whereas the use of tumour-necrosis factor-α (TNFα) and TNF-related apoptosis-inducing ligand as antitumour agents could exacerbate anaemia, thereby perpetuating tissue hypoxia and tumour progression.
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U2 - 10.1038/nrc1648
DO - 10.1038/nrc1648
M3 - Review article
C2 - 15965494
AN - SCOPUS:21744439534
SN - 1474-175X
VL - 5
SP - 543
EP - 555
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 7
ER -