TY - JOUR
T1 - The amphibian diluting segment
AU - Guggino, W. B.
AU - Oberleithner, H.
AU - Giebisch, G.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1988
Y1 - 1988
N2 - Diluting segments function to reabsorb NaCl and to reduce the osmolality of tubule fluid. These segments in amphibians are important in the conservation of NaCl. The diluting segment of mammals, the thick ascending limb, besides being an important site for the reabsorption of NaCl, supplies the energy that enables the kidney to excrete a concentrated urine. We focus in this review on the mechanisms involved in cellular and paracellular transport of Na+, K+, Cl-, and H+ in the amphibian diluting segment and how the transport of these ions is regulated. Also discussed is the action of loop diuretics and hormones on both transepithelial and cellular function. The large size of amphibian cells and their viability in various artificial conditions have allowed experiments to be performed that are not possible in the mammalian kidney, providing important information on the mechanisms of ion transport common to both mammalian thick ascending limb and amphibian diluting segment.
AB - Diluting segments function to reabsorb NaCl and to reduce the osmolality of tubule fluid. These segments in amphibians are important in the conservation of NaCl. The diluting segment of mammals, the thick ascending limb, besides being an important site for the reabsorption of NaCl, supplies the energy that enables the kidney to excrete a concentrated urine. We focus in this review on the mechanisms involved in cellular and paracellular transport of Na+, K+, Cl-, and H+ in the amphibian diluting segment and how the transport of these ions is regulated. Also discussed is the action of loop diuretics and hormones on both transepithelial and cellular function. The large size of amphibian cells and their viability in various artificial conditions have allowed experiments to be performed that are not possible in the mammalian kidney, providing important information on the mechanisms of ion transport common to both mammalian thick ascending limb and amphibian diluting segment.
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U2 - 10.1152/ajprenal.1988.254.5.f615
DO - 10.1152/ajprenal.1988.254.5.f615
M3 - Review article
C2 - 3284387
AN - SCOPUS:0023888293
SN - 0002-9513
VL - 254
SP - F615-F627
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
IS - 5 (23/5)
ER -