TY - JOUR
T1 - The adenosine-triphosphate-sensitive potassium-channel opener pinacidil is effective in blood cardioplegia
AU - Lawton, Jennifer S.
AU - Hsia, Peng Wie
AU - Damiano, Ralph J.
N1 - Funding Information:
We gratefully acknowledge the help of Luke Wolfe for statistical analysis and Cynthia T. Allen and Nancy N. Lee for technical assistance, and the generous donation of pinacidil by Leo Pharmaceuticals, Denmark. This work has been supported by a National Institutes of Health National Research Service Award grant HL09125-02 (J.S.L., R.J.D.) and National Institutes of Health R01 HL51032 (R.J.D.).
PY - 1998/9
Y1 - 1998/9
N2 - Background. This study was designed to evaluate the adenosine- triphosphate-sensitive potassium channel opener pinacidil as a blood cardioplegic agent. Methods. Using a blood-perfused, parabiotic, Langendorff rabbit model hearts underwent 30 minutes of normothermic ischemia protected with blood cardioplegia (St. Thomas' solution [n = 8] or Krebs-Henseleit solution with pinacidil [50 μmol/L, n = 8]) and 30 minutes of reperfusion. Percent recovery of developed pressure, mechanical arrest, electrical arrest, reperfusion ventricular fibrillation, percent tissue water, and myocardial oxygen consumption were compared. Results. The percent recovery of developed pressure was not different between the groups (52.3 ± 5.9 and 52.8 ± 6.9 for hyperkalemic and pinacidil cardioplegia, respectively). Pinacidil cardioplegia was associated with prolonged electrical and mechanical activity (14.4 ± 8.7 and 6.1 ± 3.9 minutes), compared with hyperkalemic cardioplegia (1.1 ± 0.6 and 1.1 ± 0.6 minutes, respectively; p < 0.05). Pinacidil cardioplegia was associated with a higher reperfusion myocardial oxygen consumption (0.6 ± 0.1 versus 0.2 ± 0.0 mL/100 g myocardium/beat; p < 0.05) and a higher percent of tissue water (79.6% ± 0.7% versus 78.6% ± 1.2%; p < 0.05). Conclusions. Systolic recovery was not different between groups, demonstrating comparable effectiveness of pinacidil and hyperkalemic warm blood cardioplegia.
AB - Background. This study was designed to evaluate the adenosine- triphosphate-sensitive potassium channel opener pinacidil as a blood cardioplegic agent. Methods. Using a blood-perfused, parabiotic, Langendorff rabbit model hearts underwent 30 minutes of normothermic ischemia protected with blood cardioplegia (St. Thomas' solution [n = 8] or Krebs-Henseleit solution with pinacidil [50 μmol/L, n = 8]) and 30 minutes of reperfusion. Percent recovery of developed pressure, mechanical arrest, electrical arrest, reperfusion ventricular fibrillation, percent tissue water, and myocardial oxygen consumption were compared. Results. The percent recovery of developed pressure was not different between the groups (52.3 ± 5.9 and 52.8 ± 6.9 for hyperkalemic and pinacidil cardioplegia, respectively). Pinacidil cardioplegia was associated with prolonged electrical and mechanical activity (14.4 ± 8.7 and 6.1 ± 3.9 minutes), compared with hyperkalemic cardioplegia (1.1 ± 0.6 and 1.1 ± 0.6 minutes, respectively; p < 0.05). Pinacidil cardioplegia was associated with a higher reperfusion myocardial oxygen consumption (0.6 ± 0.1 versus 0.2 ± 0.0 mL/100 g myocardium/beat; p < 0.05) and a higher percent of tissue water (79.6% ± 0.7% versus 78.6% ± 1.2%; p < 0.05). Conclusions. Systolic recovery was not different between groups, demonstrating comparable effectiveness of pinacidil and hyperkalemic warm blood cardioplegia.
UR - http://www.scopus.com/inward/record.url?scp=0032168822&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032168822&partnerID=8YFLogxK
U2 - 10.1016/S0003-4975(98)00471-8
DO - 10.1016/S0003-4975(98)00471-8
M3 - Article
C2 - 9768928
AN - SCOPUS:0032168822
SN - 0003-4975
VL - 66
SP - 768
EP - 773
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 3
ER -