@article{897a1787c3dc4ec281934926b5bab143,
title = "The Added Value of Crosstalk Between Developmental Circuit Neuroscience and Clinical Practice to Inform the Treatment of Adolescent Anxiety",
abstract = "Significant advances have been made in recent years regarding the developmental trajectories of brain circuits and networks, revealing links between brain structure and function. Emerging evidence highlights the importance of developmental trajectories in determining early psychiatric outcomes. However, efforts to encourage crosstalk between basic developmental neuroscience and clinical practice are limited. Here, we focus on the potential advantage of considering features of neural circuit development when optimizing treatments for adolescent patient populations. Drawing on characteristics of adolescent neurodevelopment, we highlight two examples, safety cues and incentives, that leverage insights from neural circuit development and may have great promise for augmenting existing behavioral treatments for anxiety disorders during adolescence. This commentary seeks to serve as a framework to maximize the translational potential of basic research in developmental populations for strengthening psychiatric treatments. In turn, input from clinical practice including the identification of age-specific clinically relevant phenotypes will continue to guide future basic research in the same neural circuits to better reflect clinical practices. Encouraging reciprocal communication to bridge the gap between basic developmental neuroscience research and clinical implementation is an important step toward advancing both research and practice in this domain.",
keywords = "Adolescence, Anxiety, Circuit neuroscience, Precision medicine, Reward, Safety, Translational",
author = "Meyer, {Heidi C.} and Andrea Fields and Anna Vannucci and Gerhard, {Danielle M.} and Bloom, {Paul A.} and Charlotte Heleniak and Maya Opendak and Regina Sullivan and Nim Tottenham and Callaghan, {Bridget L.} and Lee, {Francis S.}",
note = "Funding Information: The development and writing of this article was supported by National Institutes of Mental Health Pathway to Independence Awards (Grant Nos. K99MH119320 [to HCM] and K99MH124434 [to MO]), the National Center for Advancing Translational Sciences (Grant No. TL1-TR-002386 [to DMG]), the National Science Foundation (Graduate Research Fellowship [to PAB]), a Brain and Behavior Foundation NARSAD Young Investigator Award (to MO), the National Institute of Child Health and Human Development (Grant No. R37HD083217 [to RS]), the National Institute of Mental Health (Grant No. R01MH123154 [to FSL]), and the New York Community Trust (to FSL). This review is the collaborative product of thoughtful discussions between the FSL (Weill Cornell Medicine), RS (New York University), and NM (Columbia University) laboratories, including perspectives from rodent and human researchers with a core focus on affective neurodevelopment and how typical and atypical trajectories of brain development impact mental health. All authors contributed equally to conceptualization. HCM, AF, and BLC contributed to visualization. HCM, AF, AV, DMG, PAB, CH, and MO contributed to writing of the original draft. All authors contributed to writing—review and editing. The authors report no biomedical financial interests or potential conflicts of interest. Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2023",
month = apr,
doi = "10.1016/j.bpsgos.2022.02.002",
language = "English (US)",
volume = "3",
pages = "169--178",
journal = "Biological Psychiatry Global Open Science",
issn = "2667-1743",
publisher = "Elsevier BV",
number = "2",
}