The adaptable somatic repertoire

P. J. Gearhart

doi:10.1016/S0769-2625(84)80023-9

The adaptable somatic repertoire

P. J. Gearhart

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Somatic mutation introduces singles nucleotide substitutions in and around the rearranged kappa variable gene, V_k167, but not the constant gene. The high frequency of mutations is most easily explained by a mechanism of error-prone repair which occurs during several cycles of cell division. Mutations may accumulate with time after joining of the V- and J-gene segments because IgG and IgA antibodies contain more amino acid substitutions than IgM antibodies. Many variant anti-phosphorylcholine antibodies have a higher affinity for antigen than their germ-line-encoded counterparts.

Original language	English (US)
Pages (from-to)	137-142
Number of pages	6
Journal	Annales de l'Institut Pasteur - Immunology
Volume	135
Issue number	1
DOIs	https://doi.org/10.1016/S0769-2625(84)80023-9
State	Published - Jan 1 1984

Keywords

Antibody repertoire
Immunogenetics.
Immunogénétique
Phosphorylcholine
Phosphorylcholine
Répertoire anticorps

ASJC Scopus subject areas

General Medicine

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AB - Somatic mutation introduces singles nucleotide substitutions in and around the rearranged kappa variable gene, Vk167, but not the constant gene. The high frequency of mutations is most easily explained by a mechanism of error-prone repair which occurs during several cycles of cell division. Mutations may accumulate with time after joining of the V- and J-gene segments because IgG and IgA antibodies contain more amino acid substitutions than IgM antibodies. Many variant anti-phosphorylcholine antibodies have a higher affinity for antigen than their germ-line-encoded counterparts.

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KW - Immunogenetics.

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KW - Répertoire anticorps

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The adaptable somatic repertoire

Abstract

Keywords

ASJC Scopus subject areas

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