The active E rosette test: correlation with delayed cutaneous hypersensitivity

P. J. Felsburg, R. Edelman, R. H. Gilman

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


An active subpopulation of peripheral blood T lymphocytes, characterized by rapid (5 min) rosette formation with sheep erythrocytes (A RFC) was measured in normal individuals after they were skin tested with microbial antigens. A significant rise in A RFC occurred in all individuals who developed positive delayed cutaneous hypersensitivity (DCH) reactions, whereas skin test nonresponders showed no significant rise in A RFC. No similar consistent changes occured in populations of total T cells, characterized by longer (60 min) rosette formation with sheep erythrocytes, or in B cells, measured by immunofluorescence of surface immunoglobulin. The A RFC response paralleled the DCH response in timing, but not in intensity. The results provide in vivo evidence for a biologically distinct T cell subpopulation, and focus attention on the A RFC as immunologically active cells.

Original languageEnglish (US)
Pages (from-to)1110-1114
Number of pages5
Issue number4
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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