TGFβ signals through a heteromeric protein kinase receptor complex

Jeffrey L. Wrana, Liliana Attisano, Juan Cárcamo, Alejandro Zentella, Jacqueline Doody, Marikki Laiho, Xiao Fan Wang, Joan Massague

Research output: Contribution to journalArticlepeer-review

1334 Scopus citations


Transforming growth factor β (TGFβ) binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that the type II receptor requires both its kinase activity and association with another TGFβ-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGFβ, and receptor II requires receptor I to signal. This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors.

Original languageEnglish (US)
Pages (from-to)1003-1014
Number of pages12
Issue number6
StatePublished - Dec 11 1992
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'TGFβ signals through a heteromeric protein kinase receptor complex'. Together they form a unique fingerprint.

Cite this