TGF-β and Genetic Skeletal Diseases

Xiao Wang; Xu Cao

doi:10.1016/B978-0-12-801238-3.11574-0

TGF-β and Genetic Skeletal Diseases

Xiao Wang
, Xu Cao

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Transforming growth factor-β (TGF-β) controls the development and maintenance of skeleton. The mutations of TGFB and related genes lead to abnormal TGF-β signaling and various skeletal diseases. This subgroup of skeletal dysplasia can be divided as monogenic disease, which is caused by a single gene mutation, and polygenic diseases which is caused by combined effects of a group of genes as well as other risk factors. Studying these diseases enable us to understand mechanisms for development and maintenance of human skeletal tissue and lead to promising therapeutics for TGF-β-involved bone genetic diseases.

Original language	English (US)
Title of host publication	Encyclopedia of Bone Biology
Publisher	Elsevier
Pages	V1-513-V1-520
ISBN (Electronic)	9780128140826
ISBN (Print)	9780128140819
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.11574-0
State	Published - Jan 1 2020

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-12-801238-3.11574-0

Cite this

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AB - Transforming growth factor-β (TGF-β) controls the development and maintenance of skeleton. The mutations of TGFB and related genes lead to abnormal TGF-β signaling and various skeletal diseases. This subgroup of skeletal dysplasia can be divided as monogenic disease, which is caused by a single gene mutation, and polygenic diseases which is caused by combined effects of a group of genes as well as other risk factors. Studying these diseases enable us to understand mechanisms for development and maintenance of human skeletal tissue and lead to promising therapeutics for TGF-β-involved bone genetic diseases.

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ER -

TGF-β and Genetic Skeletal Diseases

Abstract

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