Abstract
Transforming growth factor β (TGFβ) binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that the type II receptor requires both its kinase activity and association with another TGFβ-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGFβ, and receptor II requires receptor I to signal. This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors.
Original language | English (US) |
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Pages (from-to) | 1003-1014 |
Number of pages | 12 |
Journal | Cell |
Volume | 71 |
Issue number | 6 |
DOIs | |
State | Published - Dec 11 1992 |
Externally published | Yes |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology