Testosterone supplementation in male obese zucker rats reduces body weight and improves insulin sensitivity but increases blood pressure

Deborah D. Davis; Arnaldo Lopez Ruiz; Licy L. Yanes; Radu Iliescu; Kuichang Yuan; Mohadetheh Moulana; Lorraine C. Racusen; Jane F. Reckelhoff

doi:10.1161/HYPERTENSIONAHA.111.180943

Testosterone supplementation in male obese zucker rats reduces body weight and improves insulin sensitivity but increases blood pressure

Deborah D. Davis, Arnaldo Lopez Ruiz, Licy L. Yanes, Radu Iliescu, Kuichang Yuan, Mohadetheh Moulana, Lorraine C. Racusen, Jane F. Reckelhoff

School of Medicine

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Androgen levels are lower in obese men as compared with normal weight individuals. However, there are no safety data regarding the chronic use of androgen supplements in middle-aged men. The present study was undertaken to determine the cardiovascular and metabolic effects of chronic (10 weeks) testosterone treatment in male obese Zucker rats, starting at 22 weeks of age, when testosterone levels were significantly decreased. Testosterone supplements increased plasma levels, 10-fold in both obese Zucker rats and lean Zucker rats. In obese Zucker rats, testosterone supplements reduced body weight, plasma insulin, and cholesterol levels and improved the oral glucose tolerance test. None of these parameters were affected in lean Zucker rats. Mean arterial pressure was significantly increased in obese Zucker rats but not lean Zucker rats. Testosterone supplements increased proteinuria and accelerated renal injury in lean Zucker rats only. Thus, treatment of obese men with chronic testosterone supplements should be done with careful monitoring of blood pressure.

Original language	English (US)
Pages (from-to)	726-731
Number of pages	6
Journal	Hypertension
Volume	59
Issue number	3
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.111.180943
State	Published - Mar 2012

Keywords

androgens
hypertension
insulin resistance
metabolic syndrome
obesity

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.1161/HYPERTENSIONAHA.111.180943

Cite this

@article{6d39ea53b2ab45779474b637289ef4e0,

title = "Testosterone supplementation in male obese zucker rats reduces body weight and improves insulin sensitivity but increases blood pressure",

abstract = "Androgen levels are lower in obese men as compared with normal weight individuals. However, there are no safety data regarding the chronic use of androgen supplements in middle-aged men. The present study was undertaken to determine the cardiovascular and metabolic effects of chronic (10 weeks) testosterone treatment in male obese Zucker rats, starting at 22 weeks of age, when testosterone levels were significantly decreased. Testosterone supplements increased plasma levels, 10-fold in both obese Zucker rats and lean Zucker rats. In obese Zucker rats, testosterone supplements reduced body weight, plasma insulin, and cholesterol levels and improved the oral glucose tolerance test. None of these parameters were affected in lean Zucker rats. Mean arterial pressure was significantly increased in obese Zucker rats but not lean Zucker rats. Testosterone supplements increased proteinuria and accelerated renal injury in lean Zucker rats only. Thus, treatment of obese men with chronic testosterone supplements should be done with careful monitoring of blood pressure.",

keywords = "androgens, hypertension, insulin resistance, metabolic syndrome, obesity",

author = "Davis, {Deborah D.} and {Lopez Ruiz}, Arnaldo and Yanes, {Licy L.} and Radu Iliescu and Kuichang Yuan and Mohadetheh Moulana and Racusen, {Lorraine C.} and Reckelhoff, {Jane F.}",

year = "2012",

month = mar,

doi = "10.1161/HYPERTENSIONAHA.111.180943",

language = "English (US)",

volume = "59",

pages = "726--731",

journal = "Hypertension",

issn = "0194-911X",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - Testosterone supplementation in male obese zucker rats reduces body weight and improves insulin sensitivity but increases blood pressure

AU - Davis, Deborah D.

AU - Lopez Ruiz, Arnaldo

AU - Yanes, Licy L.

AU - Iliescu, Radu

AU - Yuan, Kuichang

AU - Moulana, Mohadetheh

AU - Racusen, Lorraine C.

AU - Reckelhoff, Jane F.

PY - 2012/3

Y1 - 2012/3

N2 - Androgen levels are lower in obese men as compared with normal weight individuals. However, there are no safety data regarding the chronic use of androgen supplements in middle-aged men. The present study was undertaken to determine the cardiovascular and metabolic effects of chronic (10 weeks) testosterone treatment in male obese Zucker rats, starting at 22 weeks of age, when testosterone levels were significantly decreased. Testosterone supplements increased plasma levels, 10-fold in both obese Zucker rats and lean Zucker rats. In obese Zucker rats, testosterone supplements reduced body weight, plasma insulin, and cholesterol levels and improved the oral glucose tolerance test. None of these parameters were affected in lean Zucker rats. Mean arterial pressure was significantly increased in obese Zucker rats but not lean Zucker rats. Testosterone supplements increased proteinuria and accelerated renal injury in lean Zucker rats only. Thus, treatment of obese men with chronic testosterone supplements should be done with careful monitoring of blood pressure.

AB - Androgen levels are lower in obese men as compared with normal weight individuals. However, there are no safety data regarding the chronic use of androgen supplements in middle-aged men. The present study was undertaken to determine the cardiovascular and metabolic effects of chronic (10 weeks) testosterone treatment in male obese Zucker rats, starting at 22 weeks of age, when testosterone levels were significantly decreased. Testosterone supplements increased plasma levels, 10-fold in both obese Zucker rats and lean Zucker rats. In obese Zucker rats, testosterone supplements reduced body weight, plasma insulin, and cholesterol levels and improved the oral glucose tolerance test. None of these parameters were affected in lean Zucker rats. Mean arterial pressure was significantly increased in obese Zucker rats but not lean Zucker rats. Testosterone supplements increased proteinuria and accelerated renal injury in lean Zucker rats only. Thus, treatment of obese men with chronic testosterone supplements should be done with careful monitoring of blood pressure.

KW - androgens

KW - hypertension

KW - insulin resistance

KW - metabolic syndrome

KW - obesity

UR - http://www.scopus.com/inward/record.url?scp=84857557583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857557583&partnerID=8YFLogxK

U2 - 10.1161/HYPERTENSIONAHA.111.180943

DO - 10.1161/HYPERTENSIONAHA.111.180943

M3 - Article

C2 - 22275530

AN - SCOPUS:84857557583

SN - 0194-911X

VL - 59

SP - 726

EP - 731

JO - Hypertension

JF - Hypertension

IS - 3

ER -

Testosterone supplementation in male obese zucker rats reduces body weight and improves insulin sensitivity but increases blood pressure

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this