Test-retest reproducibility of a rapid method to measure brain oxygen metabolism

Peiying Liu, Feng Xu, Hanzhang Lu

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Cerebral metabolic rate of oxygen (CMRO2) is an important index of tissue viability and brain function, but this parameter cannot yet be measured routinely on clinical scanners. Recently, a noninvasive technique was proposed which estimates global CMRO2 by concomitantly measuring oxygen-extraction-fraction using T2-relaxation-under-spin-tagging MRI and pulse oximetry, and cerebral-blood-flow using phase-contrast MRI. This study sought to establish a standard acquisition procedure for this technique and to evaluate its test-retest reproducibility in healthy subjects. Each subject was examined in five sessions and each session included two measurements. Intrasession, intersession, and intersubject coefficients of variation for CMRO2 were found to be 3.84 ± 1.44% (N = 7, mean ± standard deviation), 6.59 ± 1.56%, and 8.80% respectively. These reproducibility values were comparable or slightly superior to 15O positron emission tomography (PET) results reported in the literature. It was also found that oxygen-extraction-fraction and cerebral-blood-flow tended to co-vary across sessions (P = 0.002) and subjects (P = 0.01), and their coefficients of variation were greater than that of CMRO2. The simplicity and reliability features may afford this global CMRO2 technique great potential for immediate clinical applications.

Original languageEnglish (US)
Pages (from-to)675-681
Number of pages7
JournalMagnetic resonance in medicine
Issue number3
StatePublished - Mar 1 2013
Externally publishedYes


  • cerebral blood flow
  • cerebral metabolic rate of oxygen
  • oxygen extraction fraction
  • venous oxygenation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Test-retest reproducibility of a rapid method to measure brain oxygen metabolism'. Together they form a unique fingerprint.

Cite this