Temporal relationship modeling: DTP or DT immunizations and infantile spasms

Michael Goodman, Steven H. Lamm, Martin H. Bellman

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The time relationship between DTP immunization and infantile spasms (IS) onset was examined using three models - association, temporal shift, and no-effect - and the case/control data from the National Childhood Encephalopathy Study (NCES). Infantile spasms cases classified as being previously abnormal (e.g. tuberous sclerosis complex patients) showed a no-effect relationship, whereas those classified as previously normal suggested a fit to the temporal shift model, i.e. no increase in number of cases but a shortening of time to onset of seizure. No data fit the association model. Analyses for vaccine complications should examine for temporal changes (i.e. temporal shift) in addition to increased risks.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
Issue number2-3
StatePublished - Jan 1998


  • DTP/DT immunizations
  • Infantile spasms
  • Temporal relationship

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)


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