TEM8 Interacts with the Cleaved C5 Domain of Collagen α3(VI)

Akash Nanda, Eleanor B. Carson-Walter, Steven Seaman, Thomas D. Barber, Jason Stampfl, Sujay Singh, Bert Vogelstein, Kenneth W. Kinzler, Brad St. Croix

Research output: Contribution to journalArticlepeer-review

150 Scopus citations


Tumor endothelial marker (TEM)8 was uncovered as a gene expressed predominantly in tumor endothelium, and its protein product was recently identified as the receptor for anthrax toxin. Here, we demonstrate that TEM8 protein is preferentially expressed in endothelial cells of neoplastic tissue. We used the extracellular domain of TEM8 to search for ligands and identified the α3 subunit of collagen VI as an interacting partner. The TEM8-interacting region on collagen α3(VI) was mapped to its COOH-terminal C5 domain. Remarkably, collagen α3(VI) is also preferentially expressed in tumor endothelium in a pattern concordant with that of TEM8. These results suggest that the TEM8/C5 interaction may play an important biological role in tumor angiogenesis.

Original languageEnglish (US)
Pages (from-to)817-820
Number of pages4
JournalCancer Research
Issue number3
StatePublished - Feb 1 2004

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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