Telomeres and telomerase in Alzheimer's disease: Epiphenomena or a new focus for therapeutic strategy?

Sonia Franco; Maria A. Blasco; Sandra L. Siedlak; Peggy L.R. Harris; Paula I. Moreira; George Perry; Mark A. Smith

doi:10.1016/j.jalz.2006.03.001

Telomeres and telomerase in Alzheimer's disease: Epiphenomena or a new focus for therapeutic strategy?

Sonia Franco, Maria A. Blasco, Sandra L. Siedlak, Peggy L.R. Harris, Paula I. Moreira, George Perry, Mark A. Smith

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

New approaches to the elucidation of Alzheimer disease, even those with solid data, are often ignored or dismissed as epiphenomenal when they differ from the mainstream or theoretical expectations. Here we present a new piece to the puzzle, decreases in telomere length, and telomerase expression in neuronal populations known to be vulnerable to degeneration and death in Alzheimer's disease. We can present the answers to the question "what," but the "why," "when," and "how" are not so easily answered. The goal of this report is to prompt discussion and more intensive study of this finding toward a new focus of therapeutic strategy.

Original language	English (US)
Pages (from-to)	164-168
Number of pages	5
Journal	Alzheimer's and Dementia
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/j.jalz.2006.03.001
State	Published - Jul 2006
Externally published	Yes

Keywords

Alzheimer's disease
AβPP transgenic mice
amyloid-β
telomerase
telomerase length

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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10.1016/j.jalz.2006.03.001

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title = "Telomeres and telomerase in Alzheimer's disease: Epiphenomena or a new focus for therapeutic strategy?",

abstract = "New approaches to the elucidation of Alzheimer disease, even those with solid data, are often ignored or dismissed as epiphenomenal when they differ from the mainstream or theoretical expectations. Here we present a new piece to the puzzle, decreases in telomere length, and telomerase expression in neuronal populations known to be vulnerable to degeneration and death in Alzheimer's disease. We can present the answers to the question {"}what,{"} but the {"}why,{"} {"}when,{"} and {"}how{"} are not so easily answered. The goal of this report is to prompt discussion and more intensive study of this finding toward a new focus of therapeutic strategy.",

keywords = "Alzheimer's disease, AβPP transgenic mice, amyloid-β, telomerase, telomerase length",

author = "Sonia Franco and Blasco, {Maria A.} and Siedlak, {Sandra L.} and Harris, {Peggy L.R.} and Moreira, {Paula I.} and George Perry and Smith, {Mark A.}",

note = "Funding Information: Work in the authors{\textquoteright} laboratories is supported by the NIH (AG026151), the Alzheimer{\textquoteright}s Association, Philip Morris USA Inc, and Philip Morris International. MAB is supported by the Spanish Ministry of Education and Culture, the Regional Government of Madrid, the European Union, and the Joseph Steiner Cancer Research Award.",

year = "2006",

month = jul,

doi = "10.1016/j.jalz.2006.03.001",

language = "English (US)",

volume = "2",

pages = "164--168",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "Elsevier Inc.",

number = "3",

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T1 - Telomeres and telomerase in Alzheimer's disease

T2 - Epiphenomena or a new focus for therapeutic strategy?

AU - Franco, Sonia

AU - Blasco, Maria A.

AU - Siedlak, Sandra L.

AU - Harris, Peggy L.R.

AU - Moreira, Paula I.

AU - Perry, George

AU - Smith, Mark A.

N1 - Funding Information: Work in the authors’ laboratories is supported by the NIH (AG026151), the Alzheimer’s Association, Philip Morris USA Inc, and Philip Morris International. MAB is supported by the Spanish Ministry of Education and Culture, the Regional Government of Madrid, the European Union, and the Joseph Steiner Cancer Research Award.

PY - 2006/7

Y1 - 2006/7

N2 - New approaches to the elucidation of Alzheimer disease, even those with solid data, are often ignored or dismissed as epiphenomenal when they differ from the mainstream or theoretical expectations. Here we present a new piece to the puzzle, decreases in telomere length, and telomerase expression in neuronal populations known to be vulnerable to degeneration and death in Alzheimer's disease. We can present the answers to the question "what," but the "why," "when," and "how" are not so easily answered. The goal of this report is to prompt discussion and more intensive study of this finding toward a new focus of therapeutic strategy.

AB - New approaches to the elucidation of Alzheimer disease, even those with solid data, are often ignored or dismissed as epiphenomenal when they differ from the mainstream or theoretical expectations. Here we present a new piece to the puzzle, decreases in telomere length, and telomerase expression in neuronal populations known to be vulnerable to degeneration and death in Alzheimer's disease. We can present the answers to the question "what," but the "why," "when," and "how" are not so easily answered. The goal of this report is to prompt discussion and more intensive study of this finding toward a new focus of therapeutic strategy.

KW - Alzheimer's disease

KW - AβPP transgenic mice

KW - amyloid-β

KW - telomerase

KW - telomerase length

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JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

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ER -

Telomeres and telomerase in Alzheimer's disease: Epiphenomena or a new focus for therapeutic strategy?

Abstract

Keywords

ASJC Scopus subject areas

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