@article{3e045cfd38a74b8181d6b3daa546eedf,
title = "Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia",
abstract = "Telomere shortening has been recently correlated with Alzheimer's disease status. Therefore, we hypothesized that a possible association might exist for adults with Down syndrome (DS). Using blind, quantitative telomere protein nucleic acid FISH analyses of metaphase and interphase preparations from 18 age-matched trisomy 21 female study participants with and without dementia, we have observed increased telomere shortening in adults with DS and dementia (p < .01). From this initial study, we conclude that telomere shortening is associated with dementia in this high-risk population and suggest that additional research may show that telomere shortening may be a biological marker of dementia status.",
keywords = "Dementia, Down syndrome, FISH, Interphase, Metaphase, Telomere shortening",
author = "Jenkins, {Edmund C.} and Velinov, {Milen T.} and Lingling Ye and Hong Gu and Shuyun Li and Jenkins, {Edmund C.} and Brooks, {Susan Sklower} and Deborah Pang and Devenny, {Darlynne A.} and Zigman, {Warren B.} and Nicole Schupf and Silverman, {Wayne P.}",
note = "Funding Information: Thanks are due the research participants and the cooperating agencies as well as all staff involved in this project in the Departments of Psychology and Human Genetics of the New York State Institute for Basic Research in Developmental Disabilities. We also thank W. Ted Brown, M.D., Ph.D. for constructive comments during manuscript preparation, Robert Freedland, Ph.D., for his help in preparing the figure for electronic submission, and Lawrence Black, M.S., Institute Librarian. This work was supported in part by the New York State Office of Mental Retardation and Developmental Disabilities, Alzheimer's Association Grants IIRG-99-1598 and IIRG-96-077, and by NIH Grants PO1 HD35897, RO1 AG 14673 and RO1 HD37425.",
year = "2006",
month = jul,
doi = "10.1016/j.neurobiolaging.2005.05.021",
language = "English (US)",
volume = "27",
pages = "941--945",
journal = "Neurobiology of aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "7",
}