TY - JOUR
T1 - Telomere length in white blood cell DNA and lung cancer
T2 - A pooled analysis of three prospective cohorts
AU - Seow, Wei Jie
AU - Cawthon, Richard M.
AU - Purdue, Mark P.
AU - Hu, Wei
AU - Gao, Yu Tang
AU - Huang, Wen Yi
AU - Weinstein, Stephanie J.
AU - Ji, Bu Tian
AU - Virtamo, Jarmo
AU - Hosgood, H. Dean
AU - Bassig, Bryan A.
AU - Shu, Xiao Ou
AU - Cai, Qiuyin
AU - Xiang, Yong Bing
AU - Min, Shen
AU - Chow, Wong Ho
AU - Berndt, Sonja I.
AU - Kim, Christopher
AU - Lim, Unhee
AU - Albanes, Demetrius
AU - Caporaso, Neil E.
AU - Chanock, Stephen
AU - Zheng, Wei
AU - Rothman, Nathaniel
AU - Lan, Qing
PY - 2014/8/1
Y1 - 2014/8/1
N2 - We investigated the relationship between telomere length and lung cancer in a pooled analysis from three prospective cohort studies: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, conducted among men and women in the United States, and previously published data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Trial conducted among male smokers in Finland, and the Shanghai Women's Health Study (SWHS), which is comprised primarily of never-smokers. The pooled population included 847 cases and 847 controls matched by study, age, and sex. Leukocyte telomere length was measured by a monochrome multiplex qPCR assay. We used conditional logistic regression models to calculate ORs and their 95% confidence intervals (CI) for the association between telomere length and lung cancer risk, adjusted for age and pack-years of smoking. Longer telomere length was associated with increased lung cancer risk in the pooled analysis [OR (95% CI) by quartile: 1.00; 1.24 (0.90-1.71); 1.27 (0.91-1.78); and 1.86 (1.33-2.62); P trend = 0.000022]. Findings were consistent across the three cohorts and strongest for subjects with very long telomere length, i.e., lung cancer risks for telomere length [OR (95% CI)] in the upper half of the fourth quartile were 2.41 (1.28-4.52), 2.16 (1.11-4.23), and 3.02(1.39-6.58) for the PLCO trial, the ATBC trial, and the SWHS, respectively. In addition, the association persisted among cases diagnosed more than 6 years after blood collection and was particularly evident for female adenocarcinoma cases. Telomere length in white blood cell DNA may be a biomarker of future increased risk of lung cancer in diverse populations.
AB - We investigated the relationship between telomere length and lung cancer in a pooled analysis from three prospective cohort studies: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, conducted among men and women in the United States, and previously published data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Trial conducted among male smokers in Finland, and the Shanghai Women's Health Study (SWHS), which is comprised primarily of never-smokers. The pooled population included 847 cases and 847 controls matched by study, age, and sex. Leukocyte telomere length was measured by a monochrome multiplex qPCR assay. We used conditional logistic regression models to calculate ORs and their 95% confidence intervals (CI) for the association between telomere length and lung cancer risk, adjusted for age and pack-years of smoking. Longer telomere length was associated with increased lung cancer risk in the pooled analysis [OR (95% CI) by quartile: 1.00; 1.24 (0.90-1.71); 1.27 (0.91-1.78); and 1.86 (1.33-2.62); P trend = 0.000022]. Findings were consistent across the three cohorts and strongest for subjects with very long telomere length, i.e., lung cancer risks for telomere length [OR (95% CI)] in the upper half of the fourth quartile were 2.41 (1.28-4.52), 2.16 (1.11-4.23), and 3.02(1.39-6.58) for the PLCO trial, the ATBC trial, and the SWHS, respectively. In addition, the association persisted among cases diagnosed more than 6 years after blood collection and was particularly evident for female adenocarcinoma cases. Telomere length in white blood cell DNA may be a biomarker of future increased risk of lung cancer in diverse populations.
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U2 - 10.1158/0008-5472.CAN-14-0459
DO - 10.1158/0008-5472.CAN-14-0459
M3 - Article
C2 - 24853549
AN - SCOPUS:84905493151
SN - 0008-5472
VL - 74
SP - 4090
EP - 4098
JO - Cancer Research
JF - Cancer Research
IS - 15
ER -