Telomerase activity: A marker to distinguish follicular thyroid adenoma from carcinoma

Christopher B. Umbricht; Motoyasu Saji; William H. Westra; Robert Udelsman; Martha A. Zeiger; Saraswati Sukumar

Telomerase activity: A marker to distinguish follicular thyroid adenoma from carcinoma

Christopher B. Umbricht, Motoyasu Saji, William H. Westra, Robert Udelsman, Martha A. Zeiger, Saraswati Sukumar

School of Medicine

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

The inability to distinguish microinvasive follicular thyroid cancer from benign follicular tumors preoperatively presents an important surgical dilemma. We examined 44 follicular tumors and found telomerase activity in all 11 follicular carcinomas and in 8 of 33 benign follicular tumors. It was undetectable in 22 normal thyroid tissues adjacent to the tumors. Telomerase activity may thus provide a diagnostic marker distinguishing benign from malignant follicular thyroid tumors. The ability to identify invasive follicular thyroid tumors could avert over 14,000 thyroidectomies annually in the United States, thereby significantly decreasing morbidity and health care costs.

Original language	English (US)
Pages (from-to)	2144-2147
Number of pages	4
Journal	Cancer Research
Volume	57
Issue number	11
State	Published - Jun 1 1997

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Telomerase activity: A marker to distinguish follicular thyroid adenoma from carcinoma",

abstract = "The inability to distinguish microinvasive follicular thyroid cancer from benign follicular tumors preoperatively presents an important surgical dilemma. We examined 44 follicular tumors and found telomerase activity in all 11 follicular carcinomas and in 8 of 33 benign follicular tumors. It was undetectable in 22 normal thyroid tissues adjacent to the tumors. Telomerase activity may thus provide a diagnostic marker distinguishing benign from malignant follicular thyroid tumors. The ability to identify invasive follicular thyroid tumors could avert over 14,000 thyroidectomies annually in the United States, thereby significantly decreasing morbidity and health care costs.",

author = "Umbricht, {Christopher B.} and Motoyasu Saji and Westra, {William H.} and Robert Udelsman and Zeiger, {Martha A.} and Saraswati Sukumar",

year = "1997",

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T1 - Telomerase activity

T2 - A marker to distinguish follicular thyroid adenoma from carcinoma

AU - Umbricht, Christopher B.

AU - Saji, Motoyasu

AU - Westra, William H.

AU - Udelsman, Robert

AU - Zeiger, Martha A.

AU - Sukumar, Saraswati

PY - 1997/6/1

Y1 - 1997/6/1

N2 - The inability to distinguish microinvasive follicular thyroid cancer from benign follicular tumors preoperatively presents an important surgical dilemma. We examined 44 follicular tumors and found telomerase activity in all 11 follicular carcinomas and in 8 of 33 benign follicular tumors. It was undetectable in 22 normal thyroid tissues adjacent to the tumors. Telomerase activity may thus provide a diagnostic marker distinguishing benign from malignant follicular thyroid tumors. The ability to identify invasive follicular thyroid tumors could avert over 14,000 thyroidectomies annually in the United States, thereby significantly decreasing morbidity and health care costs.

AB - The inability to distinguish microinvasive follicular thyroid cancer from benign follicular tumors preoperatively presents an important surgical dilemma. We examined 44 follicular tumors and found telomerase activity in all 11 follicular carcinomas and in 8 of 33 benign follicular tumors. It was undetectable in 22 normal thyroid tissues adjacent to the tumors. Telomerase activity may thus provide a diagnostic marker distinguishing benign from malignant follicular thyroid tumors. The ability to identify invasive follicular thyroid tumors could avert over 14,000 thyroidectomies annually in the United States, thereby significantly decreasing morbidity and health care costs.

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AN - SCOPUS:0030925697

SN - 0008-5472

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SP - 2144

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JO - Cancer Research

JF - Cancer Research

IS - 11

ER -

Telomerase activity: A marker to distinguish follicular thyroid adenoma from carcinoma

Abstract

ASJC Scopus subject areas

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