Technical Advances in Rhinologic Basic Science Research

Murugappan Ramanathan; Justin H. Turner; Andrew P. Lane

doi:10.1016/j.otc.2009.07.008

Technical Advances in Rhinologic Basic Science Research

School of Medicine

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Chronic rhinosinusitis (CRS) is the single most common self-reported chronic health condition in the United States and is estimated to affect 16% of the adult population annually. Despite the prevalence of this disease, there still exists an incomplete understanding of CRS pathophysiology. In this review, the authors highlight technological advances in rhinology: real-time polymerase chain reaction, epithelial cell culture, flow cytometry, genomics/single-nucleotide polymorphism detection, microarrays, and genetic/nongenetic animal models of sinusitis. The purpose of this review is to describe these methodologies and their contributions toward achieving a better understanding of CRS.

Original language	English (US)
Pages (from-to)	867-881
Number of pages	15
Journal	Otolaryngologic Clinics of North America
Volume	42
Issue number	5
DOIs	https://doi.org/10.1016/j.otc.2009.07.008
State	Published - Oct 2009

Keywords

Animal models
Chronic rhinosinusitis
Flow cytometry
Microarray
Polymorphisms
Real-time PCR
Sinonasal epithelial cells

ASJC Scopus subject areas

Otorhinolaryngology

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10.1016/j.otc.2009.07.008

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title = "Technical Advances in Rhinologic Basic Science Research",

abstract = "Chronic rhinosinusitis (CRS) is the single most common self-reported chronic health condition in the United States and is estimated to affect 16\% of the adult population annually. Despite the prevalence of this disease, there still exists an incomplete understanding of CRS pathophysiology. In this review, the authors highlight technological advances in rhinology: real-time polymerase chain reaction, epithelial cell culture, flow cytometry, genomics/single-nucleotide polymorphism detection, microarrays, and genetic/nongenetic animal models of sinusitis. The purpose of this review is to describe these methodologies and their contributions toward achieving a better understanding of CRS.",

keywords = "Animal models, Chronic rhinosinusitis, Flow cytometry, Microarray, Polymorphisms, Real-time PCR, Sinonasal epithelial cells",

author = "Murugappan Ramanathan and Turner, \{Justin H.\} and Lane, \{Andrew P.\}",

year = "2009",

month = oct,

doi = "10.1016/j.otc.2009.07.008",

language = "English (US)",

volume = "42",

pages = "867--881",

journal = "Otolaryngologic Clinics of North America",

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T1 - Technical Advances in Rhinologic Basic Science Research

AU - Ramanathan, Murugappan

AU - Turner, Justin H.

AU - Lane, Andrew P.

PY - 2009/10

Y1 - 2009/10

N2 - Chronic rhinosinusitis (CRS) is the single most common self-reported chronic health condition in the United States and is estimated to affect 16% of the adult population annually. Despite the prevalence of this disease, there still exists an incomplete understanding of CRS pathophysiology. In this review, the authors highlight technological advances in rhinology: real-time polymerase chain reaction, epithelial cell culture, flow cytometry, genomics/single-nucleotide polymorphism detection, microarrays, and genetic/nongenetic animal models of sinusitis. The purpose of this review is to describe these methodologies and their contributions toward achieving a better understanding of CRS.

AB - Chronic rhinosinusitis (CRS) is the single most common self-reported chronic health condition in the United States and is estimated to affect 16% of the adult population annually. Despite the prevalence of this disease, there still exists an incomplete understanding of CRS pathophysiology. In this review, the authors highlight technological advances in rhinology: real-time polymerase chain reaction, epithelial cell culture, flow cytometry, genomics/single-nucleotide polymorphism detection, microarrays, and genetic/nongenetic animal models of sinusitis. The purpose of this review is to describe these methodologies and their contributions toward achieving a better understanding of CRS.

KW - Animal models

KW - Chronic rhinosinusitis

KW - Flow cytometry

KW - Microarray

KW - Polymorphisms

KW - Real-time PCR

KW - Sinonasal epithelial cells

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DO - 10.1016/j.otc.2009.07.008

M3 - Review article

C2 - 19909865

AN - SCOPUS:70350786686

SN - 0030-6665

VL - 42

SP - 867

EP - 881

JO - Otolaryngologic Clinics of North America

JF - Otolaryngologic Clinics of North America

IS - 5

ER -

Technical Advances in Rhinologic Basic Science Research

Abstract

Keywords

ASJC Scopus subject areas

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