Tec family kinases in lymphocyte signaling and function

Edward M. Schaeffer, Pamela L. Schwartzberg

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


The Tec kinases are required for full Ca2+ mobilization in lymphocytes. Recent data suggest that this process occurs via a multiprotein complex that includes LAT and SLP-76 in T cells and BLNK/SLP-65 in B cells. Mutational analyses have revealed critical roles for Tec kinases in lymphocyte development and function.

Original languageEnglish (US)
Pages (from-to)282-288
Number of pages7
JournalCurrent Opinion in Immunology
Issue number3
StatePublished - Jun 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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