TDP-43 toxicity and the usefulness of junk

Shuying Sun, Don W. Cleveland

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.

Original languageEnglish (US)
Pages (from-to)1289-1291
Number of pages3
JournalNature genetics
Issue number12
StatePublished - Dec 2012

ASJC Scopus subject areas

  • Genetics


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