TDP-43 toxicity and the usefulness of junk

Shuying Sun; Don W. Cleveland

doi:10.1038/ng.2473

TDP-43 toxicity and the usefulness of junk

Shuying Sun, Don W. Cleveland

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.

Original language	English (US)
Pages (from-to)	1289-1291
Number of pages	3
Journal	Nature genetics
Volume	44
Issue number	12
DOIs	https://doi.org/10.1038/ng.2473
State	Published - Dec 2012

ASJC Scopus subject areas

Genetics

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abstract = "A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.",

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TDP-43 toxicity and the usefulness of junk

Abstract

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