TB meningitis in HIV-positive patients in Europe and Argentina: Clinical dutcome and factors associated with mortality

Anne Marie W. Efsen; Alexander M. Panteleev; Daniel Grint; Daria N. Podlekareva; Anna Vassilenko; Aza Rakhmanova; Indra Zeltina; Marcelo H. Losso; Robert F. Miller; Enrico Girardi; Joan Caylá; Frank A. Post; Jose M. Miro; Mathias Bruyand; Hansjakob Furrer; Niels Obel; Jens D. Lundgren; Amanda Mocroft; Ole Kirk; J. J. Toibaro; E. Warley; N. Tamayo; M. Cristina Ortiz; P. Scapelatto; E. Bottaro; F. Murano; M. Miachans; J. Contarelli; L. Massera; J. Corral; M. Hualde; C. Miglioranza; M. Corti; H. Metta; A. Casiro; R. Cuini; H. Laplume; D. David; C. Marson; S. Lupo; L. Trape; O. Garcia Messina; O. Gear; J. M. Bruguera; I. Karpov; E. Skrahina; A. Skrahin; S. Zhavoronok; V. Mitsura; D. Ruzanov; V. Bondarenko; O. Suetnov; D. Paduto; J. Gerstoft; G. Kronborg; C. Pedersen; C. S. Larsen; G. Pedersen; A. L. Laursen; L. Nielsen; J. Jensen; F. Dabis; G. Chene; S. Lawson-Ayayi; R. Thiebaut; L. Wittkop; P. Morlat; F. Bonnet; N. Bernard; M. Hessamfar; D. Lacoste; M. A. Vandenhende; M. Dupon; F. A. Dauchy; H. Dutronc; M. Longy-Boursier; P. Mercie; P. Duffau; J. Roger Schmeltz; D. Malvy; T. Pistone; M. C. Receveur; D. Neau; C. Cazanave; A. Ochoa; M. O. Vareil; J. L. Pellegrin; J. F. Viallard; C. Greib; E. Lazaro; H. Fleury; M. E. Lafon; S. Reigadas; P. Trimoulet; D. Breilh; M. Molimard; S. Bouchet; K. Titier; J. F. Moreau; I. Pellegrin; F. Haramburu; G. Arcachon; A. Dupont; Y. Gerard; L. Caunegre; K. Andre; F. Bonnal; S. Farbos; M. C. Gemain; J. Ceccaldi; S. Tchamgoue; S. De Witte; K. Courtault; E. Monlun; V. Gaborieau; P. Lataste; J. P. Meraud; I. Chossat; A. C. Carvalho; R. Basche; I. E. Hamad; B. A. Ricci; F. Maggiolo; V. Ravasio; C. Mussini; F. Prati; S. Castelletti; A. Ammassari; A. Antinori; R. Bellagamba; E. Busi Rizzi; S. Cicalini; A. Corpolongo; A. Capaldo; A. Di Caro; D. Goletti; S. Grisetti; G. Gualano; F. N. Lauria; L. Parracino; F. Palmieri; N. Petrosillo; C. Pinetti; A. Sampaolesi; M. Moroni; G. Angarano; O. Armignacco; A. d'Arminio Monforte; F. Castelli; R. Cauda; G. Di Perri; M. Galli; R. Iardino; G. Ippolito; A. Lazzarin; C. F. Perno; F. von Schloesser; P. Viale; A. Castagna; F. Ceccherini-Silberstein; A. Cozzi-Lepri; S. Lo Caputo; M. Puoti; M. Andreoni; C. Balotta; P. Bonfanti; S. Bonora; M. Borderi; M. R. Capobianchi; A. Cingolani; P. Cinque; A. De Luca; A. Di Biagio; N. Gianotti; A. Gori; G. Guaraldi; G. Lapadula; M. Lichtner; G. Madeddu; G. Marchetti; S. Marcotullio; L. Monno; E. Quiros Roldan; S. Rusconi; P. Cicconi; I. Fanti; T. Formenti; L. Galli; P. Lorenzini; A. Giacometti; A. Costantini; C. Carrisa; C. Suardi; E. Vanino; G. Verucchi; C. Minardi; T. Quirino; C. Abeli; P. E. Manconi; P. Piano; J. Vecchiet; K. Falasca; L. Sighinolfi; D. Segala; F. Mazzotta; G. Cassola; G. Viscoli; A. Alessandrini; R. Piscopo; G. Mazzarello; C. Mastroianni; V. Belvisi; I. Caramma; A. P. Castelli; G. Rizzardini; A. L. Ridolfo; R. Piolini; S. Salpietro; L. Carenzi; M. C. Moioli; C. Puzzolante; N. Abrescia; A. Chirianni; M. G. Guida; M. Gargiulo; F. Baldelli; D. Francisci; G. Parruti; T. Ursini; G. Magnani; M. A. Ursitti; V. Vullo; A. d'Avino; L. Gallo; E. Nicastri; R. Acinapura; M. Capozzi; R. Libertone; G. Tebano; A. Cattelan; M. S. Mura; P. Caramello; G. C. Orofino; M. Sciandra; G. Pellizzer; V. Manfrin; V. Riekstina; P. Aldins; D. Duiculescu; E. Malashenkov; A. Kozlov; S. Buzunova; J. F. Garcia-Goez; A. Moreno Camacho; J. A. Martinez; J. Gonzalez; F. Garcia-Alcaide; E. de Lazzari; J. M. Gatell; P. Sanchez; J. L. LopezColomes; X. Martinez-Lacasa; V. Falco; A. Imaz; I. Ocana; R. Vidal; M. A. Sambeat; A. Moreno-Martinez; A. Orcau; R. Weber; M. Battegay; B. Hirschel; M. Cavassini; E. Bernasconi; P. Schmid; M. Rickenbach; L. Campbell; A. Arenas-Pinto; N. Chentsova; J. Kjaer

doi:10.1155/2013/373601

TB meningitis in HIV-positive patients in Europe and Argentina: Clinical dutcome and factors associated with mortality

Anne Marie W. Efsen, Alexander M. Panteleev, Daniel Grint, Daria N. Podlekareva, Anna Vassilenko, Aza Rakhmanova, Indra Zeltina, Marcelo H. Losso, Robert F. Miller, Enrico Girardi, Joan Caylá, Frank A. Post, Jose M. Miro, Mathias Bruyand, Hansjakob Furrer, Niels Obel, Jens D. Lundgren, Amanda Mocroft, Ole Kirk, J. J. ToibaroE. Warley, N. Tamayo, M. Cristina Ortiz, P. Scapelatto, E. Bottaro, F. Murano, M. Miachans, J. Contarelli, L. Massera, J. Corral, M. Hualde, C. Miglioranza, M. Corti, H. Metta, A. Casiro, R. Cuini, H. Laplume, D. David, C. Marson, S. Lupo, L. Trape, O. Garcia Messina, O. Gear, J. M. Bruguera, I. Karpov, E. Skrahina, A. Skrahin, S. Zhavoronok, V. Mitsura, D. Ruzanov, V. Bondarenko, O. Suetnov, D. Paduto, J. Gerstoft, G. Kronborg, C. Pedersen, C. S. Larsen, G. Pedersen, A. L. Laursen, L. Nielsen, J. Jensen, F. Dabis, G. Chene, S. Lawson-Ayayi, R. Thiebaut, L. Wittkop, P. Morlat, F. Bonnet, N. Bernard, M. Hessamfar, D. Lacoste, M. A. Vandenhende, M. Dupon, F. A. Dauchy, H. Dutronc, M. Longy-Boursier, P. Mercie, P. Duffau, J. Roger Schmeltz, D. Malvy, T. Pistone, M. C. Receveur, D. Neau, C. Cazanave, A. Ochoa, M. O. Vareil, J. L. Pellegrin, J. F. Viallard, C. Greib, E. Lazaro, H. Fleury, M. E. Lafon, S. Reigadas, P. Trimoulet, D. Breilh, M. Molimard, S. Bouchet, K. Titier, J. F. Moreau, I. Pellegrin, F. Haramburu, G. Arcachon, A. Dupont, Y. Gerard, L. Caunegre, K. Andre, F. Bonnal, S. Farbos, M. C. Gemain, J. Ceccaldi, S. Tchamgoue, S. De Witte, K. Courtault, E. Monlun, V. Gaborieau, P. Lataste, J. P. Meraud, I. Chossat, A. C. Carvalho, R. Basche, I. E. Hamad, B. A. Ricci, F. Maggiolo, V. Ravasio, C. Mussini, F. Prati, S. Castelletti, A. Ammassari, A. Antinori, R. Bellagamba, E. Busi Rizzi, S. Cicalini, A. Corpolongo, A. Capaldo, A. Di Caro, D. Goletti, S. Grisetti, G. Gualano, F. N. Lauria, L. Parracino, F. Palmieri, N. Petrosillo, C. Pinetti, A. Sampaolesi, M. Moroni, G. Angarano, O. Armignacco, A. d'Arminio Monforte, F. Castelli, R. Cauda, G. Di Perri, M. Galli, R. Iardino, G. Ippolito, A. Lazzarin, C. F. Perno, F. von Schloesser, P. Viale, A. Castagna, F. Ceccherini-Silberstein, A. Cozzi-Lepri, S. Lo Caputo, M. Puoti, M. Andreoni, C. Balotta, P. Bonfanti, S. Bonora, M. Borderi, M. R. Capobianchi, A. Cingolani, P. Cinque, A. De Luca, A. Di Biagio, N. Gianotti, A. Gori, G. Guaraldi, G. Lapadula, M. Lichtner, G. Madeddu, G. Marchetti, S. Marcotullio, L. Monno, E. Quiros Roldan, S. Rusconi, P. Cicconi, I. Fanti, T. Formenti, L. Galli, P. Lorenzini, A. Giacometti, A. Costantini, C. Carrisa, C. Suardi, E. Vanino, G. Verucchi, C. Minardi, T. Quirino, C. Abeli, P. E. Manconi, P. Piano, J. Vecchiet, K. Falasca, L. Sighinolfi, D. Segala, F. Mazzotta, G. Cassola, G. Viscoli, A. Alessandrini, R. Piscopo, G. Mazzarello, C. Mastroianni, V. Belvisi, I. Caramma, A. P. Castelli, G. Rizzardini, A. L. Ridolfo, R. Piolini, S. Salpietro, L. Carenzi, M. C. Moioli, C. Puzzolante, N. Abrescia, A. Chirianni, M. G. Guida, M. Gargiulo, F. Baldelli, D. Francisci, G. Parruti, T. Ursini, G. Magnani, M. A. Ursitti, V. Vullo, A. d'Avino, L. Gallo, E. Nicastri, R. Acinapura, M. Capozzi, R. Libertone, G. Tebano, A. Cattelan, M. S. Mura, P. Caramello, G. C. Orofino, M. Sciandra, G. Pellizzer, V. Manfrin, V. Riekstina, P. Aldins, D. Duiculescu, E. Malashenkov, A. Kozlov, S. Buzunova, J. F. Garcia-Goez, A. Moreno Camacho, J. A. Martinez, J. Gonzalez, F. Garcia-Alcaide, E. de Lazzari, J. M. Gatell, P. Sanchez, J. L. LopezColomes, X. Martinez-Lacasa, V. Falco, A. Imaz, I. Ocana, R. Vidal, M. A. Sambeat, A. Moreno-Martinez, A. Orcau, R. Weber, M. Battegay, B. Hirschel, M. Cavassini, E. Bernasconi, P. Schmid, M. Rickenbach, L. Campbell, A. Arenas-Pinto, N. Chentsova, J. Kjaer

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Objectives. The study aimed at describing characteristics and outcome of tuberculous meningitis (TBM) in HIV-positive patients and comparing these parameters with those of extrapulmonary TB (TBEP) and pulmonary TB (TBP). Methods. Kaplan-Meier estimation and Poisson regression models were used to assess the mortality following TB diagnosis and to evaluate potential prognostic factors for the 3 groups of TB patients separately. Results. A total of 100 patients with TBM, 601 with TBEP, and 371 TBP were included. Patients with TBM had lower CD4 cell counts and only 17.0% received antiretroviral therapy (ART) at TB diagnosis. The cumulative probability of death at 12 months following TB was 51.2% for TBM (95% CI 41.4-61.6%), 12.3% for TBP (8.9-15.7%), and 19.4% for TBEP (16.1-22.6) (P < 0.0001; log-rank test). For TBM, factors associated with a poorer prognosis were not being on ART (adjusted incidence rate ratio (aIRR) 4.00 (1.72-9.09), a prior AIDS diagnosis (aIRR = 4.82 (2.61-8.92)), and receiving care in Eastern Europe (aIRR = 5.41 (2.58-11.34))). Conclusions. TBM among HIV-positive patients was associated with a high mortality rate, especially for patients from Eastern Europe and patients with advanced HIV-infection, which urgently calls for public health interventions to improve both TB and HIV aspects of patient management.

Original language	English (US)
Article number	373601
Journal	BioMed research international
Volume	2013
DOIs	https://doi.org/10.1155/2013/373601
State	Published - Jan 1 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

Access to Document

10.1155/2013/373601

Cite this

Efsen, A. M. W., Panteleev, A. M., Grint, D., Podlekareva, D. N., Vassilenko, A., Rakhmanova, A., Zeltina, I., Losso, M. H., Miller, R. F., Girardi, E., Caylá, J., Post, F. A., Miro, J. M., Bruyand, M., Furrer, H., Obel, N., Lundgren, J. D., Mocroft, A., Kirk, O., ... Kjaer, J. (2013). TB meningitis in HIV-positive patients in Europe and Argentina: Clinical dutcome and factors associated with mortality. BioMed research international, 2013, Article 373601. https://doi.org/10.1155/2013/373601

Efsen, AMW, Panteleev, AM, Grint, D, Podlekareva, DN, Vassilenko, A, Rakhmanova, A, Zeltina, I, Losso, MH, Miller, RF, Girardi, E, Caylá, J, Post, FA, Miro, JM, Bruyand, M, Furrer, H, Obel, N, Lundgren, JD, Mocroft, A, Kirk, O, Toibaro, JJ, Warley, E, Tamayo, N, Cristina Ortiz, M, Scapelatto, P, Bottaro, E, Murano, F, Miachans, M, Contarelli, J, Massera, L, Corral, J, Hualde, M, Miglioranza, C, Corti, M, Metta, H, Casiro, A, Cuini, R, Laplume, H, David, D, Marson, C, Lupo, S, Trape, L, Garcia Messina, O, Gear, O, Bruguera, JM, Karpov, I, Skrahina, E, Skrahin, A, Zhavoronok, S, Mitsura, V, Ruzanov, D, Bondarenko, V, Suetnov, O, Paduto, D, Gerstoft, J, Kronborg, G, Pedersen, C, Larsen, CS, Pedersen, G, Laursen, AL, Nielsen, L, Jensen, J, Dabis, F, Chene, G, Lawson-Ayayi, S, Thiebaut, R, Wittkop, L, Morlat, P, Bonnet, F, Bernard, N, Hessamfar, M, Lacoste, D, Vandenhende, MA, Dupon, M, Dauchy, FA, Dutronc, H, Longy-Boursier, M, Mercie, P, Duffau, P, Roger Schmeltz, J, Malvy, D, Pistone, T, Receveur, MC, Neau, D, Cazanave, C, Ochoa, A, Vareil, MO, Pellegrin, JL, Viallard, JF, Greib, C, Lazaro, E, Fleury, H, Lafon, ME, Reigadas, S, Trimoulet, P, Breilh, D, Molimard, M, Bouchet, S, Titier, K, Moreau, JF, Pellegrin, I, Haramburu, F, Arcachon, G, Dupont, A, Gerard, Y, Caunegre, L, Andre, K, Bonnal, F, Farbos, S, Gemain, MC, Ceccaldi, J, Tchamgoue, S, De Witte, S, Courtault, K, Monlun, E, Gaborieau, V, Lataste, P, Meraud, JP, Chossat, I, Carvalho, AC, Basche, R, Hamad, IE, Ricci, BA, Maggiolo, F, Ravasio, V, Mussini, C, Prati, F, Castelletti, S, Ammassari, A, Antinori, A, Bellagamba, R, Busi Rizzi, E, Cicalini, S, Corpolongo, A, Capaldo, A, Di Caro, A, Goletti, D, Grisetti, S, Gualano, G, Lauria, FN, Parracino, L, Palmieri, F, Petrosillo, N, Pinetti, C, Sampaolesi, A, Moroni, M, Angarano, G, Armignacco, O, d'Arminio Monforte, A, Castelli, F, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Perno, CF, von Schloesser, F, Viale, P, Castagna, A, Ceccherini-Silberstein, F, Cozzi-Lepri, A, Lo Caputo, S, Puoti, M, Andreoni, M, Balotta, C, Bonfanti, P, Bonora, S, Borderi, M, Capobianchi, MR, Cingolani, A, Cinque, P, De Luca, A, Di Biagio, A, Gianotti, N, Gori, A, Guaraldi, G, Lapadula, G, Lichtner, M, Madeddu, G, Marchetti, G, Marcotullio, S, Monno, L, Quiros Roldan, E, Rusconi, S, Cicconi, P, Fanti, I, Formenti, T, Galli, L, Lorenzini, P, Giacometti, A, Costantini, A, Carrisa, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, PE, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Castelli, AP, Rizzardini, G, Ridolfo, AL, Piolini, R, Salpietro, S, Carenzi, L, Moioli, MC, Puzzolante, C, Abrescia, N, Chirianni, A, Guida, MG, Gargiulo, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, MA, Vullo, V, d'Avino, A, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Cattelan, A, Mura, MS, Caramello, P, Orofino, GC, Sciandra, M, Pellizzer, G, Manfrin, V, Riekstina, V, Aldins, P, Duiculescu, D, Malashenkov, E, Kozlov, A, Buzunova, S, Garcia-Goez, JF, Moreno Camacho, A, Martinez, JA, Gonzalez, J, Garcia-Alcaide, F, de Lazzari, E, Gatell, JM, Sanchez, P, LopezColomes, JL, Martinez-Lacasa, X, Falco, V, Imaz, A, Ocana, I, Vidal, R, Sambeat, MA, Moreno-Martinez, A, Orcau, A, Weber, R, Battegay, M, Hirschel, B, Cavassini, M, Bernasconi, E, Schmid, P, Rickenbach, M, Campbell, L, Arenas-Pinto, A, Chentsova, N & Kjaer, J 2013, 'TB meningitis in HIV-positive patients in Europe and Argentina: Clinical dutcome and factors associated with mortality', BioMed research international, vol. 2013, 373601. https://doi.org/10.1155/2013/373601

@article{81fd6e4e45594228a8bee0eef1c9a109,

title = "TB meningitis in HIV-positive patients in Europe and Argentina: Clinical dutcome and factors associated with mortality",

abstract = "Objectives. The study aimed at describing characteristics and outcome of tuberculous meningitis (TBM) in HIV-positive patients and comparing these parameters with those of extrapulmonary TB (TBEP) and pulmonary TB (TBP). Methods. Kaplan-Meier estimation and Poisson regression models were used to assess the mortality following TB diagnosis and to evaluate potential prognostic factors for the 3 groups of TB patients separately. Results. A total of 100 patients with TBM, 601 with TBEP, and 371 TBP were included. Patients with TBM had lower CD4 cell counts and only 17.0% received antiretroviral therapy (ART) at TB diagnosis. The cumulative probability of death at 12 months following TB was 51.2% for TBM (95% CI 41.4-61.6%), 12.3% for TBP (8.9-15.7%), and 19.4% for TBEP (16.1-22.6) (P < 0.0001; log-rank test). For TBM, factors associated with a poorer prognosis were not being on ART (adjusted incidence rate ratio (aIRR) 4.00 (1.72-9.09), a prior AIDS diagnosis (aIRR = 4.82 (2.61-8.92)), and receiving care in Eastern Europe (aIRR = 5.41 (2.58-11.34))). Conclusions. TBM among HIV-positive patients was associated with a high mortality rate, especially for patients from Eastern Europe and patients with advanced HIV-infection, which urgently calls for public health interventions to improve both TB and HIV aspects of patient management.",

author = "Efsen, {Anne Marie W.} and Panteleev, {Alexander M.} and Daniel Grint and Podlekareva, {Daria N.} and Anna Vassilenko and Aza Rakhmanova and Indra Zeltina and Losso, {Marcelo H.} and Miller, {Robert F.} and Enrico Girardi and Joan Cayl{\'a} and Post, {Frank A.} and Miro, {Jose M.} and Mathias Bruyand and Hansjakob Furrer and Niels Obel and Lundgren, {Jens D.} and Amanda Mocroft and Ole Kirk and Toibaro, {J. J.} and E. Warley and N. Tamayo and {Cristina Ortiz}, M. and P. Scapelatto and E. Bottaro and F. Murano and M. Miachans and J. Contarelli and L. Massera and J. Corral and M. Hualde and C. Miglioranza and M. Corti and H. Metta and A. Casiro and R. Cuini and H. Laplume and D. David and C. Marson and S. Lupo and L. Trape and {Garcia Messina}, O. and O. Gear and Bruguera, {J. M.} and I. Karpov and E. Skrahina and A. Skrahin and S. Zhavoronok and V. Mitsura and D. Ruzanov and V. Bondarenko and O. Suetnov and D. Paduto and J. Gerstoft and G. Kronborg and C. Pedersen and Larsen, {C. S.} and G. Pedersen and Laursen, {A. L.} and L. Nielsen and J. Jensen and F. Dabis and G. Chene and S. Lawson-Ayayi and R. Thiebaut and L. Wittkop and P. Morlat and F. Bonnet and N. Bernard and M. Hessamfar and D. Lacoste and Vandenhende, {M. A.} and M. Dupon and Dauchy, {F. A.} and H. Dutronc and M. Longy-Boursier and P. Mercie and P. Duffau and {Roger Schmeltz}, J. and D. Malvy and T. Pistone and Receveur, {M. C.} and D. Neau and C. Cazanave and A. Ochoa and Vareil, {M. O.} and Pellegrin, {J. L.} and Viallard, {J. F.} and C. Greib and E. Lazaro and H. Fleury and Lafon, {M. E.} and S. Reigadas and P. Trimoulet and D. Breilh and M. Molimard and S. Bouchet and K. Titier and Moreau, {J. F.} and I. Pellegrin and F. Haramburu and G. Arcachon and A. Dupont and Y. Gerard and L. Caunegre and K. Andre and F. Bonnal and S. Farbos and Gemain, {M. C.} and J. Ceccaldi and S. Tchamgoue and {De Witte}, S. and K. Courtault and E. Monlun and V. Gaborieau and P. Lataste and Meraud, {J. P.} and I. Chossat and Carvalho, {A. C.} and R. Basche and Hamad, {I. E.} and Ricci, {B. A.} and F. Maggiolo and V. Ravasio and C. Mussini and F. Prati and S. Castelletti and A. Ammassari and A. Antinori and R. Bellagamba and {Busi Rizzi}, E. and S. Cicalini and A. Corpolongo and A. Capaldo and {Di Caro}, A. and D. Goletti and S. Grisetti and G. Gualano and Lauria, {F. N.} and L. Parracino and F. Palmieri and N. Petrosillo and C. Pinetti and A. Sampaolesi and M. Moroni and G. Angarano and O. Armignacco and {d'Arminio Monforte}, A. and F. Castelli and R. Cauda and {Di Perri}, G. and M. Galli and R. Iardino and G. Ippolito and A. Lazzarin and Perno, {C. F.} and {von Schloesser}, F. and P. Viale and A. Castagna and F. Ceccherini-Silberstein and A. Cozzi-Lepri and {Lo Caputo}, S. and M. Puoti and M. Andreoni and C. Balotta and P. Bonfanti and S. Bonora and M. Borderi and Capobianchi, {M. R.} and A. Cingolani and P. Cinque and {De Luca}, A. and {Di Biagio}, A. and N. Gianotti and A. Gori and G. Guaraldi and G. Lapadula and M. Lichtner and G. Madeddu and G. Marchetti and S. Marcotullio and L. Monno and {Quiros Roldan}, E. and S. Rusconi and P. Cicconi and I. Fanti and T. Formenti and L. Galli and P. Lorenzini and A. Giacometti and A. Costantini and C. Carrisa and C. Suardi and E. Vanino and G. Verucchi and C. Minardi and T. Quirino and C. Abeli and Manconi, {P. E.} and P. Piano and J. Vecchiet and K. Falasca and L. Sighinolfi and D. Segala and F. Mazzotta and G. Cassola and G. Viscoli and A. Alessandrini and R. Piscopo and G. Mazzarello and C. Mastroianni and V. Belvisi and I. Caramma and Castelli, {A. P.} and G. Rizzardini and Ridolfo, {A. L.} and R. Piolini and S. Salpietro and L. Carenzi and Moioli, {M. C.} and C. Puzzolante and N. Abrescia and A. Chirianni and Guida, {M. G.} and M. Gargiulo and F. Baldelli and D. Francisci and G. Parruti and T. Ursini and G. Magnani and Ursitti, {M. A.} and V. Vullo and A. d'Avino and L. Gallo and E. Nicastri and R. Acinapura and M. Capozzi and R. Libertone and G. Tebano and A. Cattelan and Mura, {M. S.} and P. Caramello and Orofino, {G. C.} and M. Sciandra and G. Pellizzer and V. Manfrin and V. Riekstina and P. Aldins and D. Duiculescu and E. Malashenkov and A. Kozlov and S. Buzunova and Garcia-Goez, {J. F.} and {Moreno Camacho}, A. and Martinez, {J. A.} and J. Gonzalez and F. Garcia-Alcaide and {de Lazzari}, E. and Gatell, {J. M.} and P. Sanchez and LopezColomes, {J. L.} and X. Martinez-Lacasa and V. Falco and A. Imaz and I. Ocana and R. Vidal and Sambeat, {M. A.} and A. Moreno-Martinez and A. Orcau and R. Weber and M. Battegay and B. Hirschel and M. Cavassini and E. Bernasconi and P. Schmid and M. Rickenbach and L. Campbell and A. Arenas-Pinto and N. Chentsova and J. Kjaer",

year = "2013",

month = jan,

day = "1",

doi = "10.1155/2013/373601",

language = "English (US)",

volume = "2013",

journal = "BioMed research international",

issn = "2314-6133",

publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - TB meningitis in HIV-positive patients in Europe and Argentina

T2 - Clinical dutcome and factors associated with mortality

AU - Efsen, Anne Marie W.

AU - Panteleev, Alexander M.

AU - Grint, Daniel

AU - Podlekareva, Daria N.

AU - Vassilenko, Anna

AU - Rakhmanova, Aza

AU - Zeltina, Indra

AU - Losso, Marcelo H.

AU - Miller, Robert F.

AU - Girardi, Enrico

AU - Caylá, Joan

AU - Post, Frank A.

AU - Miro, Jose M.

AU - Bruyand, Mathias

AU - Furrer, Hansjakob

AU - Obel, Niels

AU - Lundgren, Jens D.

AU - Mocroft, Amanda

AU - Kirk, Ole

AU - Toibaro, J. J.

AU - Warley, E.

AU - Tamayo, N.

AU - Cristina Ortiz, M.

AU - Scapelatto, P.

AU - Bottaro, E.

AU - Murano, F.

AU - Miachans, M.

AU - Contarelli, J.

AU - Massera, L.

AU - Corral, J.

AU - Hualde, M.

AU - Miglioranza, C.

AU - Corti, M.

AU - Metta, H.

AU - Casiro, A.

AU - Cuini, R.

AU - Laplume, H.

AU - David, D.

AU - Marson, C.

AU - Lupo, S.

AU - Trape, L.

AU - Garcia Messina, O.

AU - Gear, O.

AU - Bruguera, J. M.

AU - Karpov, I.

AU - Skrahina, E.

AU - Skrahin, A.

AU - Zhavoronok, S.

AU - Mitsura, V.

AU - Ruzanov, D.

AU - Bondarenko, V.

AU - Suetnov, O.

AU - Paduto, D.

AU - Gerstoft, J.

AU - Kronborg, G.

AU - Pedersen, C.

AU - Larsen, C. S.

AU - Pedersen, G.

AU - Laursen, A. L.

AU - Nielsen, L.

AU - Jensen, J.

AU - Dabis, F.

AU - Chene, G.

AU - Lawson-Ayayi, S.

AU - Thiebaut, R.

AU - Wittkop, L.

AU - Morlat, P.

AU - Bonnet, F.

AU - Bernard, N.

AU - Hessamfar, M.

AU - Lacoste, D.

AU - Vandenhende, M. A.

AU - Dupon, M.

AU - Dauchy, F. A.

AU - Dutronc, H.

AU - Longy-Boursier, M.

AU - Mercie, P.

AU - Duffau, P.

AU - Roger Schmeltz, J.

AU - Malvy, D.

AU - Pistone, T.

AU - Receveur, M. C.

AU - Neau, D.

AU - Cazanave, C.

AU - Ochoa, A.

AU - Vareil, M. O.

AU - Pellegrin, J. L.

AU - Viallard, J. F.

AU - Greib, C.

AU - Lazaro, E.

AU - Fleury, H.

AU - Lafon, M. E.

AU - Reigadas, S.

AU - Trimoulet, P.

AU - Breilh, D.

AU - Molimard, M.

AU - Bouchet, S.

AU - Titier, K.

AU - Moreau, J. F.

AU - Pellegrin, I.

AU - Haramburu, F.

AU - Arcachon, G.

AU - Dupont, A.

AU - Gerard, Y.

AU - Caunegre, L.

AU - Andre, K.

AU - Bonnal, F.

AU - Farbos, S.

AU - Gemain, M. C.

AU - Ceccaldi, J.

AU - Tchamgoue, S.

AU - De Witte, S.

AU - Courtault, K.

AU - Monlun, E.

AU - Gaborieau, V.

AU - Lataste, P.

AU - Meraud, J. P.

AU - Chossat, I.

AU - Carvalho, A. C.

AU - Basche, R.

AU - Hamad, I. E.

AU - Ricci, B. A.

AU - Maggiolo, F.

AU - Ravasio, V.

AU - Mussini, C.

AU - Prati, F.

AU - Castelletti, S.

AU - Ammassari, A.

AU - Antinori, A.

AU - Bellagamba, R.

AU - Busi Rizzi, E.

AU - Cicalini, S.

AU - Corpolongo, A.

AU - Capaldo, A.

AU - Di Caro, A.

AU - Goletti, D.

AU - Grisetti, S.

AU - Gualano, G.

AU - Lauria, F. N.

AU - Parracino, L.

AU - Palmieri, F.

AU - Petrosillo, N.

AU - Pinetti, C.

AU - Sampaolesi, A.

AU - Moroni, M.

AU - Angarano, G.

AU - Armignacco, O.

AU - d'Arminio Monforte, A.

AU - Castelli, F.

AU - Cauda, R.

AU - Di Perri, G.

AU - Galli, M.

AU - Iardino, R.

AU - Ippolito, G.

AU - Lazzarin, A.

AU - Perno, C. F.

AU - von Schloesser, F.

AU - Viale, P.

AU - Castagna, A.

AU - Ceccherini-Silberstein, F.

AU - Cozzi-Lepri, A.

AU - Lo Caputo, S.

AU - Puoti, M.

AU - Andreoni, M.

AU - Balotta, C.

AU - Bonfanti, P.

AU - Bonora, S.

AU - Borderi, M.

AU - Capobianchi, M. R.

AU - Cingolani, A.

AU - Cinque, P.

AU - De Luca, A.

AU - Di Biagio, A.

AU - Gianotti, N.

AU - Gori, A.

AU - Guaraldi, G.

AU - Lapadula, G.

AU - Lichtner, M.

AU - Madeddu, G.

AU - Marchetti, G.

AU - Marcotullio, S.

AU - Monno, L.

AU - Quiros Roldan, E.

AU - Rusconi, S.

AU - Cicconi, P.

AU - Fanti, I.

AU - Formenti, T.

AU - Galli, L.

AU - Lorenzini, P.

AU - Giacometti, A.

AU - Costantini, A.

AU - Carrisa, C.

AU - Suardi, C.

AU - Vanino, E.

AU - Verucchi, G.

AU - Minardi, C.

AU - Quirino, T.

AU - Abeli, C.

AU - Manconi, P. E.

AU - Piano, P.

AU - Vecchiet, J.

AU - Falasca, K.

AU - Sighinolfi, L.

AU - Segala, D.

AU - Mazzotta, F.

AU - Cassola, G.

AU - Viscoli, G.

AU - Alessandrini, A.

AU - Piscopo, R.

AU - Mazzarello, G.

AU - Mastroianni, C.

AU - Belvisi, V.

AU - Caramma, I.

AU - Castelli, A. P.

AU - Rizzardini, G.

AU - Ridolfo, A. L.

AU - Piolini, R.

AU - Salpietro, S.

AU - Carenzi, L.

AU - Moioli, M. C.

AU - Puzzolante, C.

AU - Abrescia, N.

AU - Chirianni, A.

AU - Guida, M. G.

AU - Gargiulo, M.

AU - Baldelli, F.

AU - Francisci, D.

AU - Parruti, G.

AU - Ursini, T.

AU - Magnani, G.

AU - Ursitti, M. A.

AU - Vullo, V.

AU - d'Avino, A.

AU - Gallo, L.

AU - Nicastri, E.

AU - Acinapura, R.

AU - Capozzi, M.

AU - Libertone, R.

AU - Tebano, G.

AU - Cattelan, A.

AU - Mura, M. S.

AU - Caramello, P.

AU - Orofino, G. C.

AU - Sciandra, M.

AU - Pellizzer, G.

AU - Manfrin, V.

AU - Riekstina, V.

AU - Aldins, P.

AU - Duiculescu, D.

AU - Malashenkov, E.

AU - Kozlov, A.

AU - Buzunova, S.

AU - Garcia-Goez, J. F.

AU - Moreno Camacho, A.

AU - Martinez, J. A.

AU - Gonzalez, J.

AU - Garcia-Alcaide, F.

AU - de Lazzari, E.

AU - Gatell, J. M.

AU - Sanchez, P.

AU - LopezColomes, J. L.

AU - Martinez-Lacasa, X.

AU - Falco, V.

AU - Imaz, A.

AU - Ocana, I.

AU - Vidal, R.

AU - Sambeat, M. A.

AU - Moreno-Martinez, A.

AU - Orcau, A.

AU - Weber, R.

AU - Battegay, M.

AU - Hirschel, B.

AU - Cavassini, M.

AU - Bernasconi, E.

AU - Schmid, P.

AU - Rickenbach, M.

AU - Campbell, L.

AU - Arenas-Pinto, A.

AU - Chentsova, N.

AU - Kjaer, J.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objectives. The study aimed at describing characteristics and outcome of tuberculous meningitis (TBM) in HIV-positive patients and comparing these parameters with those of extrapulmonary TB (TBEP) and pulmonary TB (TBP). Methods. Kaplan-Meier estimation and Poisson regression models were used to assess the mortality following TB diagnosis and to evaluate potential prognostic factors for the 3 groups of TB patients separately. Results. A total of 100 patients with TBM, 601 with TBEP, and 371 TBP were included. Patients with TBM had lower CD4 cell counts and only 17.0% received antiretroviral therapy (ART) at TB diagnosis. The cumulative probability of death at 12 months following TB was 51.2% for TBM (95% CI 41.4-61.6%), 12.3% for TBP (8.9-15.7%), and 19.4% for TBEP (16.1-22.6) (P < 0.0001; log-rank test). For TBM, factors associated with a poorer prognosis were not being on ART (adjusted incidence rate ratio (aIRR) 4.00 (1.72-9.09), a prior AIDS diagnosis (aIRR = 4.82 (2.61-8.92)), and receiving care in Eastern Europe (aIRR = 5.41 (2.58-11.34))). Conclusions. TBM among HIV-positive patients was associated with a high mortality rate, especially for patients from Eastern Europe and patients with advanced HIV-infection, which urgently calls for public health interventions to improve both TB and HIV aspects of patient management.

AB - Objectives. The study aimed at describing characteristics and outcome of tuberculous meningitis (TBM) in HIV-positive patients and comparing these parameters with those of extrapulmonary TB (TBEP) and pulmonary TB (TBP). Methods. Kaplan-Meier estimation and Poisson regression models were used to assess the mortality following TB diagnosis and to evaluate potential prognostic factors for the 3 groups of TB patients separately. Results. A total of 100 patients with TBM, 601 with TBEP, and 371 TBP were included. Patients with TBM had lower CD4 cell counts and only 17.0% received antiretroviral therapy (ART) at TB diagnosis. The cumulative probability of death at 12 months following TB was 51.2% for TBM (95% CI 41.4-61.6%), 12.3% for TBP (8.9-15.7%), and 19.4% for TBEP (16.1-22.6) (P < 0.0001; log-rank test). For TBM, factors associated with a poorer prognosis were not being on ART (adjusted incidence rate ratio (aIRR) 4.00 (1.72-9.09), a prior AIDS diagnosis (aIRR = 4.82 (2.61-8.92)), and receiving care in Eastern Europe (aIRR = 5.41 (2.58-11.34))). Conclusions. TBM among HIV-positive patients was associated with a high mortality rate, especially for patients from Eastern Europe and patients with advanced HIV-infection, which urgently calls for public health interventions to improve both TB and HIV aspects of patient management.

UR - http://www.scopus.com/inward/record.url?scp=84896862405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896862405&partnerID=8YFLogxK

U2 - 10.1155/2013/373601

DO - 10.1155/2013/373601

M3 - Article

C2 - 24699884

AN - SCOPUS:84896862405

SN - 2314-6133

VL - 2013

JO - BioMed research international

JF - BioMed research international

M1 - 373601

ER -

TB meningitis in HIV-positive patients in Europe and Argentina: Clinical dutcome and factors associated with mortality

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