@article{94158f7720e84f1e935a6fec6c4648e3,
title = "Taste responses to linoleic acid: A crowdsourced population study",
abstract = "Dietary fats serve multiple essential roles in human health but may also contribute to acute and chronic health complications. Thus, understanding mechanisms that influence fat ingestion are critical. All sensory systems may contribute relevant cues to fat detection, with the most recent evidence supporting a role for the sense of taste. Taste detection thresholds for fat vary markedly between individuals and responses are not normally distributed. Genetics may contribute to these observations. Using crowdsourced data obtained from families visiting the Denver Museum of Nature & Science, our objective was to estimate the heritability of fat taste (oleogustus). A pedigree analysis was conducted with 106 families (643 individuals) who rated the fat taste intensity of graded concentrations of linoleic acid (LA) embedded in taste strips. The findings estimate that 19% (P = 0.043) of the variability of taste response to LA relative to baseline is heritable at the highest concentration tested.",
keywords = "Citizen science, Crowdsourcing, Fat taste, Heredity estimate, Oleogustus",
author = "{on behalf of The Genetics of Taste Lab Citizen Scientists} and Garneau, {Nicole L.} and Nuessle, {Tiffany M.} and Tucker, {Robin M.} and Mengjie Yao and Santorico, {Stephanie A.} and Mattes, {Richard D.} and Michael Archer and Sunanda Babu and Emma Boxer and Wendy Covert and Vanessa Dorrance and Katelyn Engel and Michael Hamby and Laura Harmacek and Joyce Hutchens and Sally Huynh and Rachel Jones and Torry Knodell and Wim Leenhouts and Stephania Lukjan and Kathy Lutchi and Joshua Mak and Dani Meyers and Anjelica Miranda and Jericho Oviedo and Brian Reinhart and Wilbur Reusser and Valerie Schowinsky and Claire Simon and Sean Stahle and Sonnie Talley and Rudy Torres and Weston Truman and {Van De Wege}, Johanna and Tyler Wilson and Diane Woltkamp",
note = "Funding Information: The authors wish to thank current and previous volunteer citizen scientists, interns, and staff members in both the Genetics of Taste Lab and on the Expedition Health core team for their support of the crowdsourcing research model. Special thanks to Laura Hancock, MD/PhD candidate in the Human Medical Genetics and Genomics Program at the University of Colorado Anschutz Medical Campus, for developing a qRT-PCR protocol suitable for our citizen scientists. Members of the Genetics of Taste Lab Citizen Science corps that contributed to this work include (in alphabetical order): Michael Archer, Sunanda Babu, Emma Boxer, Wendy Covert, Vanessa Dorrance, Katelyn Engel, Michael Hamby, Laura Harmacek, Joyce Hutchens, Sally Huynh, Rachel Jones, Torry Knodell, Wim Leenhouts, Stephania Lukjan, Kathy Lutchi, Joshua Mak, Dani Meyers, Anjelica Miranda, Jericho Oviedo, Brian Reinhart, Wilbur Reusser, Valerie Schowinsky, Claire Simon, Sean Stahle, Sonnie Talley, Rudy Torres, Weston Truman, Johanna Van De Wege, Tyler Wilson, and Diane Woltkamp. This work was supported by the National Center for Research Resources, National Institutes of Health [1R25RR025066] and the University of Colorado Denver, CLAS Research Innovation Seed Program, and US Department of Agriculture Hatch Grant [208684]. Funding Information: This work was supported by the National Center for Research Resources, National Institutes of Health [1R25RR025066] and the University of Colorado Denver, CLAS Research Innovation Seed Program, and US Department of Agriculture Hatch Grant [208684]. Publisher Copyright: {\textcopyright} The Author 2017. Published by Oxford University Press. All rights reserved.",
year = "2017",
month = nov,
day = "1",
doi = "10.1093/chemse/bjx058",
language = "English (US)",
volume = "42",
pages = "769--775",
journal = "Chemical Senses",
issn = "0379-864X",
publisher = "Oxford University Press",
number = "9",
}